·糖尿病临床研究·

　　【摘要】 目的 探讨T2DM口服降糖药(OADs)治疗不佳应用格列美脲联合甘精胰岛素治疗的临床效果。 方法 将102例OADs治疗不佳的T2DM患者按随机数字表法分为观察组和对照组。观察组予格列美脲联合甘精胰岛素;对照组予格列美脲联合中性鱼精蛋白锌胰岛素(NPH)。治疗20周后，比较两组的疗效和安全性。 结果 治疗后，观察组FBG、2 hBG、BMI、HbA1c较对照组下降(P<0.05);组内比较，除BMI外，FBG、2 hBG 、HbA1c差异有统计学意义(P<0.05);观察组HDL-C升高幅度大于对照组，而TG、TC、LDL-C下降幅度大于对照组(P<0.05)。结论 OADs治疗不佳的患者甘精胰岛素对比NPH胰岛素联合格列美年疗效前者更优。

　　【关键词】糖尿病，2型;格列美脲;甘精胰岛素;临床分析

　　【Abstract】Objective To study clinical efficacy of insulin glargine versus protamine zinc insulin plus glimepiride on type 2 diabetes(T2DM). Methods The 102 T2DM patients with poorly controlled blood glucose by oral antidiabetic drugs (OAD) were rondamized into two groups of insulin glargine (observation)versus protamine zinc insulin (control) plus glimepiride treatment for 20 weeks. The efficacy and safety were compared between two groups after 20 weeks of treatment. Results After treatment, the decrement value of fasting plasma glucose (FPG), 2 hour glucose tolerance (2hPG), HbA1c, TG, TC, and LDL-C were more in observation group than in control group(P<0.05), while, the increment value of HDL-C was more in observation group than in control group(P<0.05).Conclusion Compared with protamine zinc insulin together with glimepiride, combination of insulin glargine and glimepiride can effectively control T2DM patients with poorly controlled blood glucose by OAD.

　　【Key words】Type 2 diabetes;Glenn beautiful urea;Insulin;Clinical analysis