糖尿病性肾脏疾病

　　【摘要】目的 分析BP与T2DM患者尿白蛋白/肌酐(UACR)的关系，探讨BP对糖尿病慢性肾脏疾病(CKD)的影响。方法 收集330例T2DM患者资料，测BP和UACR。根据UACR水平分为<30 mg/24 h组、30~299 mg/24 h组和﹥300 mg/24 h组，检测各组BP及UACR等水平的变化情况。 结果 BP组及高血压组蛋白尿发生率为31.4%及64.2%。病程<10年、病程10~20年及病程>20年BP正常者与高血压者比较，总蛋白尿的发生率分别为0%、8%，7.6%、30.1%，0%、51.7% ( P<0.01)。<30 mg/24 h组、﹥300 mg/24 h组高血压发生率为30.3%及69.1%;病程<10年、病程10~20年及病程>20年患者中<30 mg/24 h组、30~299 mg/24 h组和﹥300 mg/24 h组比较，高血压发生率分别为28.9%、67.4%、100%，33.3%、50.9%、76.7%，25.0%、84.6%、100% ( P<0.01)。 结论 高血压加速CKD的发生。

　　【关键词】高血压;尿白蛋白/肌酐;糖尿病，2型;糖尿病慢性肾脏疾病;血压

　　[Abstract] Objective To analyze the relationship between BP (blood pressure) and UACR (urinary albumin to creatinine ratio) in patients with T2DM (type 2 diabetes mellitus) and probe into the effect of BP on CKD (Chronic kidney disease of diabetes). Methods Data of 330 hospitalized patients with T2DM were collected, BP and UACR were tested. According to the UACR level, they were divided into < 30 mg/24 h group, 30~299 mg/24 h and > 300 mg/24 h group, and changes of BP and UACR levels in each group were detected. Results The incidence rates of albuminuria in groups with normotension and hypertension were 31.4 % and 64.2 %, respectively. The incidence rates of albuminuria in mormotension group and BP group with different courses (< 10 years, 10~20 years and > 20 years) were 0 %, 8 %, 7.6 %, 30.1 %, 0 % and 51.7 %, respectively (P < 0.01). The incidence rates of hypertension in groups (< 30 mg/24 h) and (> 300 mg/24 h) were 30.3 % and 69.1 %, respectively. Among patients with different courses of disease (< 10 years, 10~20 years and > 20 years), the incidence rates of hypertension in groups (< 30 mg/24 h), (30~299 mg/24 h) and (> 300 mg/24 h) were 28.9 %, 67.4 %, 100 %, 33.3 %, 50.9 %, 76.7 %, 25.0 %, 84.6 %, 100 %, respectively (P < 0.01). Conclusion These results suggested that hypertension hastened the development of chronic kidney disease of diabetes.

　　[Key words] Hypertension; Urinary Albumin/Creatinine Ratio (UACR); Diabetes mellitus, type 2 (T2DM); Chronic kidney disease of diabetes (CKD); Blood pressure (BP)