•糖尿病与大血管病•

　　【摘要】 目的 研究每日40mg阿托伐他汀对预防T2DM患者颈动脉硬化的影响。 方法 将T2DM合并颈动脉斑块患者随机分为给予每日40 mg阿托伐他汀治疗的观察(n=31)组和给予常规剂量阿托伐他汀治疗的对照(n=30)组，分别于治疗前和治疗后12周检测血脂指标、颈动脉斑块情况及内皮功能情况。 结果 观察组TG、TC、LDL-C、载脂蛋白B水平、颈动脉内膜层厚度、血管内径和斑块面积均低于对照组(P<0.05);载脂蛋白A-Ⅰ水平以及内皮依赖性血管舒张功能均高于对照组(P<0.05);两组HDL-C比较差异无统计学意义。 结论 每日40 mg阿托伐他汀有助于改善血脂代谢水平、颈动脉斑块情况以及内皮舒张功能，对于预防T2DM患者颈动脉硬化有积极价值。

　　【关键词】 阿托伐他汀;糖尿病，2型;颈动脉斑块;动脉硬化

　　【Abstract】 Objective To study the effect of 40 mg daily of atorvastatin on preventing carotid artery atherosclerosis in T2DM patients. Methods Patients with T2DM and carotid plaques were enrolled and randomly divided into observation group (n=31) given 40 mg daily of atorvastatin and control group (n=30) given routine doses of atorvastatin. Then blood lipid indexes, carotid artery plaque condition and endothelium dependent dilatation were detected before treatment and after 12 weeks. Results TG [(2.8±0.3) mmol/L], TC [(1.1±0.1) mmol/L], LDL-C [(1.7±0.2) mmol/L], ApoB level [(1.1±0.1) g/L], IMT [(0.88±0.15) mm], vessel diameter [(5.1±0.6) mm] and plaque area [(15.2±3.4) mm2] of observation group were less than control group (P<0.05); endothelium dependent dilatation EDD% (12.4±0.3) and ApoA-Ⅰ [(1.3±0.2) g/L] were higher than control group (P<0.05); HDL-C of two groups had no statistical significance. Conclusion 40 mg daily of atorvastatin has positive value to prevent carotid artery atherosclerosis in patients with T2DM, and it is helpful to improve blood lipid metabolism, carotid artery plaque and endothelial function.

　　【Key words】 Atorvastatin; Diabetes mellitus, type 2; Carotid artery plaque; Atherosclerosis