【摘要】　目的 探讨T2DM患者产生白蛋白尿的相关因素以及与下肢动脉病变(LEAD)的相关性。 方法 将T2DM患者1342例分为正常白蛋白尿组108例、微量白蛋白尿组1042例和临床白蛋白尿组192例进行比较，分析白蛋白尿的相关因素。 结果 1342例患者中，UAlb异常率92.0%。微量白蛋白尿组、临床白蛋白尿组LEAD发生率分别为36.5%、45.8%，高于微量白蛋白尿组14.8%。腹围、SBP、BUN和血肌酐增高是T2DM患者产生白蛋白尿的危险因素，肾小球滤过率增高是保护因素。 结论 白蛋白尿排泄增高的T2DM患者LEAD发生率高，T2DM患者白蛋白尿与LEAD发生密切相关。

　　【关键词】 糖尿病，2型;白蛋白尿;下肢动脉病变;相关因素

　　【Abstract】 Objective To investigate the influential factor between different levels of albuminuria and lower extremity arterial diseases (LEAD) in T2DM. Methods 1342 T2DM patients were divided into three groups: 108 cases in normal albuminuria group, 1042 cases in microalbuminuria group and 192 cases in clinical albuminuria group. Measurement and comparison of the ankle brachial index and other related clinical indicators were performed among three groups. Using multifactor logistic regression, relationship between albuminuria occurrence and the related factors was analyzed. Results Of 1342 T2DM patients, the abnormal rate of urinary albumin accounted for 92.0%. Fibrinogen (Fbg), urea nitrogen, creatinine and SBP were significantly higher in clinical albuminuria group than in normal albuminuria group and microalbuminuria group. Glomerular filtration rate (GFR) was less in clinical albuminuria group than in normal albuminuria group and microalbuminuria group. The LEAD incidence was 36.5% in microalbuminuria group and 45.8% in clinical albuminuria group, both were higher than 14.8% (P<0.01)in normal albuminuria group. HbA1c was higher in microalbuminuria group than in clinical albuminuria group and normal albuminuria group.Abdominal circumference, blood pressure, BUN and increased Scr were relative factors for urinary albumin development in patients with T2DM. Conclusion Albuminuria excretion is positively correlated with the incidence of LEAD in T2DM.

　　【Key words】 Diabetes mellitus，type 2;Albuminuria;Lower extremity arterial diseases (LEAD);Related factors