【摘要】目的 探讨MS对新诊断T2DM患者心血管疾病(CVD)危险因素及Framingham危险评分(FRV)的影响。 方法 选取既往无冠心病(CHD)病史的新诊断T2DM患者320例，分为单纯T2DM(T2DM)组108例和合并MS(MS)组212例，将MS组进一步分为含3个组分(MS3)亚组143例和含4个组分(MS4)亚组69例。收集一般资料、吸烟史和人体测量学指标，检测FPG、FIns、血脂、高敏C反应蛋白和HbA1c等，计算BMI、胰岛素抵抗指数(HOMA-IR)和FRV。 结果 MS组BMI、BP、TC、TG、LDL-C、hsC-RP、HOMA-IR和FRV高危及中危组比例高于T2DM组(P<0.05或P<0.01)，MS4亚组BP、TC、TG、LDL-C、hsC-RP、HOMA-IR和FRV中危组比例高于MS3亚组(P<0.05或P<0.01)。Logistic回归分析显示，与T2DM组相比，MS组FRV高危及非低危组危险比(OR)值分别为2.036、2.498，与MS3亚组相比，MS4亚组FRV高危及非低危组OR值分别为2.406、14.182。 结论 既往无CHD病史的新诊断T2DM合并MS患者CVD危险因素水平更高，FRV非低危组比例更大。

　　【关键词】糖尿病，2型;代谢综合征;心血管疾病;Framingham风险评分

　　【Abstract】Objective To investigate the impact of MS on cardiovascular disease (CVD) risk factors and Framingham risk variables (FRV) in newly-diagnosed T2DM patients without coronary heart disease. Methods 320 newly-diagnosed T2DM patients without coronary heart disease (CHD) were selected. They were divided into T2DM group (n=108) and MS group (n=212). Based on the number of MS components, MS group was subdivided into MS3(included three components, n=143)and MS4 (included four components, n=69) subgroups. General information, smoking history and anthropometry data were collected. FPG, FIns, TC, TG, HDL-C, LDL-C, hsC-RP and HbA1c were detected. BMI, HOMA-IR and FRV were calculated. Results BMI, blood pressure, TC, TG, LDL-C, hsC-RP, HOMA-IR and the proportion of high and middle risk of FRV were significantly higher in MS group than in T2DM group (P<0.05 or P<0.01). Blood pressure, TC, TG, LDL-C, hsC-RP, HOMA-IR and proportion of middle risk of FRV were significantly higher in MS4 subgroup than in MS3 subgroup (P<0.05 or P<0.01). Compared with T2DM group, the odds ratio (OR) of high and non-low risk of FRV in MS group was 2.036, 2.498 (P<0.01)respectively. Compared with MS3 subgroup, the OR of high and non-low risk of FRV in MS4 subgroup was 2.406, 14.182 (P<0.05)respectively. Conclusion In the newly-diagnosed T2DM patients without CHD, MS may increase the risk of CVD.

　　【Key words】Diabetes mellitus，type 2;Metabolic syndrome (MS);Cardiovascular disease (CVD);Framingham risk value (FRV)