【摘要】目的探讨2型糖尿病(T2DM)患者高尿酸血症的有关因素。方法选取住院的T2DM患者605例，根据男性和绝经后女性血尿酸≥420μmoul/l ，绝经前女性血尿酸≥360μmoul/l，将T2DM患者分为正常尿酸(NUA)组523例与高尿酸(HUA)组82例。比较两组临床指标及糖尿病合并症和并发症的差异。结果(1)HUA组糖尿病病程、甘油三酯(TG)、体质指数(BMI)、血肌酐(SCr)、尿白蛋白/肌酐(UACR)均高于NUA组(p<0.05)，而糖化血红蛋白(HbA1c)、空腹血糖(FPG)、高密度脂蛋白胆固醇(HDL-C)、踝肱指数(ABI)均低于NUA组(p<0.05)。(2)HUA组白蛋白尿、高血压、冠心病、糖尿病视网膜病变的发病率均高于NUA组(p<0.05)。(3)多元线性回归分析示：HbA1c、TG、HDL、BMI、Scr为高尿酸血症的影响因素(p<0.01)。结论 T2DM患者高尿酸血症与高血压、血脂异常和肥胖有关，高尿酸血症相关于糖尿病慢性并发症的发生。

　　【关键词】糖尿病，2型;高尿酸血症;危险因素

　　【Abstract】Objective To investigate the factors related to hyperuricemia in type 2 diabetes mellitus (T2DM). Methods The clinical data of 605 patients with T2DM were collected.According to serum uric acid levels, 605 patients with T2DM were divided into normal serum uric acid(NUA) group(n=523) and hyperuricemia (HUA) group(n=82).The differences in clinical indices and complications were compared between two groups. Results(1)Hyperuricemia group showed higher triglycerides(TG), body mass index(BMI), serum creatinine (SCr), the uric albumin/creatinine(UACR)(all p<0.05),and lower hemoglobin A1c(HbA1c),fasting plasma glucose(FPG) ,high density lipoprotein cholesterol(HDL-C)，ankle brachial index(ABI) than those in the group with normal uric acid(all p<0.05). (2) Group with hyperuricemia showed higher incidence rates of albuminuria, coronary heart disease, hypertension, diabetic retinopathy than those in the group with normal uric acid(all p<0.05).(3)Multiple linear regression analysis showed.that hyperuricemia was positively related to the serum TG, HDL, BMI, Scr and negatively the HbA1c(all p<0.01). Conclusion The level of hyperuricemia in patients with T2DM is closely related to hypertension, dyslipidemia and adiposity. Hyperuricemia participate in the development of diabetic chronic complications

　　【Key words】 Diabetes mellitus, type 2 ;Hyperuricemia;Risk factors