糖尿病胰岛素治疗

　　【摘要】 目的 比较地特胰岛素(Det)与甘精胰岛素(Gla)联合速效胰岛素治疗T2DM疗效。 方法 将血糖控制不佳T2DM患者70例分为Det组和Gla组，治疗24周，比较两组治疗前后HbAlc、FPG、晚餐前血糖(PDPG)、胰岛素剂量、体重增加及低血糖发生情况。 结果 经24周治疗，两组HbA1c、FPG均下降(P<0.01)，组间比较差异无统计学意义。两组PDPG均下降(P<0.01)，组间比较差异有统计学意义(P<0.01)。Gla组胰岛素剂量较Det组低，平均体重增加较Det组高(P<0.05)。Det、Gla组发生低血糖风险分别为8.69、8.92事件/患者年。 结论 1次/d Det联合速效胰岛素是治疗血糖控制不佳T2DM患者的有效方案之一。[s1]

　　【关键词】地特胰岛素;甘精胰岛素;糖尿病，2型

　　【Abstract】 Objective To compare the clinical effects between insulin detemir and insulin glargine treatment in T2DM patients. Methods 70 cases of poor blood sugar control of T2DM patients were divided into insulin detemir and glargine groups. At 24 weeks of the study , the measured parameters before and after treatment included HbA1c, FPG, pre-dinner plasma glucose (PDPG), insulin doses, weight gain and the incidence of hypoglycemia. Results HbA1c and FPG were decreased after 24 weeks of treatment (P<0.01), but there was no significant difference between two groups. PDPG were significantly decreased both between two groups and intra-groups (P<0.01). The doses of insulin were lower in glargine group than in detemir group (P<0.05). Average weight gain was lower in detemir group than in glargine group (P<0.05). Risk of hypoglycemia was 8.69 and 8.92 events/patients years in detemir and glargine groups respectively. Conclusion Insulin detemir daily joint short-acting insulin is effective for the treatment of poor glycemic control patients with T2DM.

　　【Key words】Insulin detemir;Insulin glargine;Diabetes[s3] mellitus，type 2