糖尿病大血管病变

　　【摘要】 目的 观察T2DM患者血清γ-谷氨酰转肽酶(GGT)的变化，探讨GGT与T2DM患者颈动脉粥样硬化 (CAS) 的关系。 方法 选择T2DM(T2DM组)患者35例，正常对照者(NC组)40名，分析GGT和CAS的关系。 结果 T2DM组GGT高于NC组(P<0.05);T2DM组CAS者15例，其中9例为双侧;NC组CAS者2名，其中1例为双侧。Logistic回归分析示，年龄、高血糖和GGT是颈动脉斑块的独立预测因素。 结论 T2DM患者GGT水平高于正常人群，同时T2DM患者GGT水平升高与颈动脉粥样斑块形成相关。

　　【关键词】γ-谷氨酰转移酶;糖尿病，2型;颈动脉粥样硬化;胰岛素抵抗;氧化应激

　　[Abstract] Objective To observe changes in serum gamma-glutamyltransferase (GGT) and its association with carotid atherosclerosis. Methods 35 T2DM patients hospitalized in Endocrinology Department of the Second Hospital of HeBei Medical University from February 2011 to February 2012 were collected. Meantime, 40 healthy cases were taken as the control group Results GGT level was higher in T2DM patients than in the control group; 15 cases had carotid atherosclerosis (CAS) in T2DM group, including 9 cases with bilateral carotid plaques. On the other hand, there were only 2 cases with CAS in the control group, including 1 case with bilateral carotid plaques. Logistic regression analysis showed that age, hyperglycemia and serum GGT were the independent predictors of carotid plaques. Conclusion Serum levels of GGT in patients with T2DM are higher than those in healthy people, and the elevated serum GGT is closely related to carotid plaques.

　　[Key words] Gamma-glutamyltransferase; Diabetes mellitus，type 2; Carotid atherosclerosis; Insulin resistance; Oxidative stress