·糖尿病神经病变·

　　【摘要】 目的 探讨血糖波动与2型糖尿病周围神经病变(DPN)严重程度的相关性。 方法 DPN患者126例，根据多伦多神经病变评分分为轻、中、重度组。所有患者均采用动态血糖监测系统连续监测72 h，计算平均血糖水平(MBG)、日内平均血糖波动幅度(MAGE)、血糖波动最大幅度(DMMG)、血糖标准差(SD)，并记录年龄、性别、病程、BMI、HbA1c及一般生化指标。 结果 MBG、MAGE、SD随着神经病变严重程度的增加而增加(P<0.05)，神经病变严重程度分别与MBG、MAGE呈正相关(β=0.249、0.196，P<0.05)。 结论 T2DM患者血糖波动可能与周围神经病变严重程度相关。

　　【关键词】 糖尿病，2型;血糖波动;动态血糖监测;神经病变

Correlation researches between peripheral neuropathy and blood glucose fluctuation in type 2 diabetes patients WANG Guo-feng , YIN Dong , XU Ning, et al. Department of Endocrinology, the first people’s hospital of LianYunGang, LianYunGang222000, China

Corresponding author:YIN Dong, E-mail：yindong6233@163.com

　　【Abstract】 Objective To investigate the relationship between peripheral neuropathy and blood glucose fluctuation in type 2 diabetes patients. Methods 216 diabetic peripheral neuropathy patients were divided into mild，moderate，severe groups according to the TCSS score system. The fluctuating feature of 72 hours blood glucose were recorded by continuous glucose monitoring system (CGMS),then counted the MBG,MAGE,DMMG,SD , and the age, gender, disease duration, BMI , HbA1c and biochemical indicators were also recorded. Results DMMG , MAGE , SD increases with growing severity of the neuropathy. severity of the neuropathy was positively correlated with MBG, MAGE (β= 0.249,0.196, P<0.05). Conclusion There is a correlation between the blood glucose fluctuation and peripheral neuropathy in T2DM.

　　【Key words】 Diabetes mellitus，type 2;Glucose variability;Continuous glucose