·胰岛素抵抗及其相关疾病·

　　【摘要】 目的 探讨不同糖耐量人群HbA1c与载脂蛋白A5(ApoA5)及血脂的关系。方法 将研究对象分为T2DM组98例、IGR组87例及糖耐量正常组(NGT组)100名。比较各组HbA1c、ApoA5、TC、TG、LDL-C和HDL-C水平。 结果 T2DM、IGR组HbA1c，TC，TG，LDL-C高于NGT组，ApoA5、HDL-C低于NGT组(P<0.05);;T2DM组HbA1c，TC，TG，LDL-C高于IGR组，ApoA5、HDL-C低于IGR组(P<0.05)。糖耐量异常程度与血浆ApoA5呈负相关，ApoA5与TC，TG，LDL-C呈负相关，与HDL-C呈正相关。结论 ApoA5、HbA1c与脂代谢异常可能互为因果关系，因此，积极调节ApoA5、血脂水平可能对防治糖耐量异常及糖尿病有重要作用。

　　【关键词】糖尿病，2型;糖调节受损;糖化血红蛋白;载脂蛋白A5;血脂

The relationship of apolipoprotein A5 diversity and glucose ,blood lipid in different sugar tolerance crowd YANG Yan ,DENG Hua-cong,GAN Lin,et al. Department of Endocrinology ,First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China

Corresponding author：DENG Hua-cong，E-mail：deng_huacong@yahoo.com.cn

　　【Abstract】 Objective To investigete the relationship among glycosylated hemoglobin (HbA1c), apolipoprotein A5(ApoA5)and blood lipid in individuals with different glucose tolerance. Methods 98 patients with newly diagnosed type 2 diabetes mellitus (T2DM group),87 patients with impaired glucose regulation(IGR group),100 individuals with normal glucose tolerance (NGT group , as control) were enrolled.HbA1c,ApoA5,total cholesterol(TC),triglyeride(TG), low density lipoprotein(LDL-C)，high density lipoprotein cholesterol(HDL-C) of each group were determined and compared. Results The levels of HbA1c, TC，TG，LDL-C were significantly higher in T2DM group than in IGR group and NGT group(P<0.05),the levels of ApoA5,HDL-C were lower in T2DM group than in NGT group (P<0.05).The levels of HbA1c, TC，TG，LDL-C were significantly higherin IGR group than in NGT group(P<0.05), the levels of ApoA5,HDL-C were lower in IGR group than in NGT group (P<0.05).The levels of HbA1c,TC,TG,LDL-C were significantly higherin T2DM group than in IGR group(P<0.05),the levels of ApoA5,HDL-C were lower than in IGR group (P <0.05).Conclusion The level of glucose tolerance abnormality is negatively correlated with ApoA5. ApoA5 is negatively correlated with TC，TG，LDL-C. ApoA5 is positively correlated with HDL-C. We presume that the ApoA5，HbA1c and blood lipid have a mutual cause and effect relationship ,therefore, positive regulation of the levels of ApoA5, blood lipids may play an important role in prevention and cure of abnormal glucose tolerance and diabetes

　　【Key words】 Diabetes mellitus，type 2;Impaired glucose regulation(IGR);Glycosylated hemoglobin;Blood lipid