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 2型糖尿病患者周围神经病变危险因素分析

来自:中国糖尿病杂志  编辑:陈晓文 马红英 赵鹏 任雅瑾 陈玥 钟文|点击数:|2014-12-16

  糖尿病神经病变

  【摘要】 目的 探讨T2DM住院患者糖尿病周围神经病变(DPN)患病率及危险因素。 方法 选取T2DM住院患者205例,以多伦多临床评分系统(TCSS)评分为DPN诊断标准,分为DPN组和无DPN(NDPN)组,比较两组各项指标。 结果 DPN患病率43.9%。DNP组年龄[(57.76±12.50)vs(49.50±13.28)岁]、病程[(8.12±2.50)vs(5.67±1.99)年]、体重[(62.50±10.46)vs(67.03±13.43)kg]、DBP[(82.79±13.69)vs(86.98±12.18)mmHg]、UAlb/Cr[(211.66±26.78)vs(44.21±9.77)mg/24 h]和DR患病率[41(45.5%)vs20(17.4%)]与NDPN组比较差异有统计学意义(P<0.01)。Logistic多元回归分析显示,年龄、病程、UAlb/Cr、合并DR与DPN发病呈正相关。 结论 年龄、病程、UAlb/Cr、合并DR是T2DM住院患者DPN发病的危险因素。

  【关键词】糖尿病,2型;糖尿病周围神经病变;危险因素

  【Abstract】 Objective To discuss the prevalence and risk factors of diabetic peripheral neuropathy (DPN) in patients with T2DM. Methods 205 hospitalized patients with collected. According to Toronto clinical scoring system (TCSS), the patients were divided into DPN group and non-DPN (NDPN) group. The data were compared between two groups. Results The prevalence of DPN was 43.9%. There were significant difference between DPN and NDPN group in age [(57.76±12.50)vs(49.50±13.28)years], course [(8.12±2.50)vs(5.67±1.99)years], weight [(62.50±10.46)vs(67.03±13.43)kg], DBP [(82.79±13.69)vs(86.98±12.18)mmHg], UAlb/Cr [(211.66±26.78)vs(44.21±9.77)mg/24 h] and DR occurrence [41(45.5%)vs 20(17.4%)] (all P<0.01). The logistic regression analysis showed that age, course of disease, UAlb/Cr, occurrence of DR were positively correlated with DPN occurrence. Conclusion Age, course of disease, UAlb/Cr, co-occurrence of DR are the high risk factors of DPN occurrence in patients with T2DM.

  【Key words】Diabetes mellitus,type 2;Diabetic peripheral neuropathy (DPN);Risk factors

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