·糖尿病与大血管病·

　　2型糖尿病合并高血压患者高敏C反应蛋白与肱踝脉搏波速度的变化及其临床意义

　　边涛 李云 杨鹏

　　【摘要】 目的 探讨T2DM合并高血压患者高敏C反应蛋白(hsC-RP)与臂踝脉搏波速度(baPWV)的关系。 方法 分析比T2DM合并高血压组(T2DM+EH组)、T2DM组及正常对照组(NC组)hsCRP和baPWV水平及其相关性。 结果 hsCRP水平T2DM+EH组(3.5±0.8) mg/L、T2DM组(3.3±1.1) mg/L均高于NC组(1.4±1.0) mg/L(P<0.05)。T2DM+EH组baPWV(2196.1±218.6) cm/s高于其他两组(P<0.05);T2DM组baPWV(2010.9±231.7 cm/s)高于NC组(1617.4±198.2) cm/s P<0.05)。各组hsCRP水平和baPWV均有较好的相关性。 结论 T2DM+EH患者hsCRP和baPWV同时升高，且二者之间有较好的相关性。

　　【关键词】糖尿病，2型;高血压;高敏C反应蛋白;臂踝脉搏波速度

Variation and clinical significance of hsCRP and baPWV in diabetes mellitus patients with hypertension BIAN Tao, LI Yun, YANG Peng. Department of Endocrinology, Kailuan Linxi Hospital, Tangshan 063103, China

　　【Abstract】Objective To explore the variation and clinical significance of high sensitive C reaction protein (hsCRP) and brachial ankle pulse wave velocity (baPWV) in diabetes mellitus patients with hypertension. Methods The 203 subjects who visited doctor in our hospital from Mar. 2010 to Mar. 2012 were recruited in our study. The levels of hsCRP and baPWV were compared among the control group (NC, n=78), diabetes mellitus group (T2DM, n=56), and diabetes mellitus with hypertension group (T2DM+EH, n=69). Results The levels of hsCRP in the NC, DM, and DM+EH groups were (1.4±1.0)mg/L, (3.3±1.1)mg/L, and (3.5±0.8)mg/L respectively, and the difference was significant (P<0.05). The levels of baPWV in the three groups were 1617.4cm/s, 2010.9cm/s, and 2196.1cm/s respectively, and the difference was also significant (P<0.05). The levels of hsCRP and baPWV in each of the three groups had association with each other. Conclusion The levels of hsCRP and baPWV increased simultaneously in diabetes mellitus patients with hypertension, and there is an association between hsCRP and baPWV.

　　【Key word】 Diabetes mellitus, type 2; Hypertension; High sensitive C reaction protein (hsCRP); Brachial ankle pulse wave velocity (baPWV)