·糖尿病与代谢综合征·

　　我国中老年女性血尿酸和心律失常关系的研究

　　梁飞 高彬 李社莉 党永进 王琼 房玉杰 明洁 付建芳 姬秋和

　　【摘要】 目的 通过横断面研究观察我国中老年女性血尿酸(SUA)和心律失常风险的关系。 方法 以2007～2008年我国糖尿病和代谢紊乱研究数据库中，同时具备SUA和心电图明尼苏达码>50岁女性为研究对象，按SUA水平分为低、中、高3组。以OR值和Meta分析比较心律失常风险在组间的差异。以Logistic 回归和Meta分析比较校正其他心血管事件危险因素后，心律失常风险在不同组间的差异。 结果 共2172例纳入分析，HSUA组心律失常风险高于MSUA组(OR：1.98, 95%CI：1.12～3.50)和LSUA组(OR：1.73, 95%CI：1.11～2.71)。校正其他心血管事件危险因素后，HSUA组心律失常风险仍高于MSUA组(校正后OR：2.36, 95%CI：1.26～4.39)和LSUA组(校正后OR：1.80, 95%CI：1.11～2.90)。MSUA组和LSUA组心律失常风险比较差异无统计学意义(OR: 0.84, 95%CI: 0.55～1.30)。 结论 高尿酸血症与我国中老年女性心律失常独立相关，SUA升高，是我国中老年女性危险因素之一。

　　【关键字】中老年女性;血尿酸;心律失常

Analysis on the association between serum uric acid and arrhythmia in middle- and old-aged women in China LIANG Fei, GAO Bin, LI She-li, et al. Department of Endocrinology, The First Hospital Affiliated to the Fourth Military Medical University, Shanxi 710032, China.

Corresponding author: JI Qiu-he, E-mail: jqiuhe@fmmu.edu.cn.

　　【Abstract】 Objective To investigate the association between serum uric acid (SUA) and the risk for arrhythmia in middle- and old-aged women in China by a cross-sectional survey. Methods Women with SUA and Minnesota code of electrocardiogram (ECG), aged above 50 years, were chosen to be study population. The study population was split into three groups: low SUA group, middle SUA group, and high SUA group. OR and Meta-analysis were used to compare arrhythmia risk between SUA groups. Logistic regression and Meta-analysis were applied to compare arrhythmia risk after adjusting for other risk factors of cardiovascular disease (CVD) between SUA groups. Results A total of 2172 people were enrolled in the study. Individuals in the high SUA group had higher arrhythmia risk than those in the middle SUA group (OR: 1.98, 95%CI: 1.12～3.50) and in the low SUA group (OR: 1.73, 95%CI: 1.11～2.71). After adjusting for other CVD risk factors, individuals in the high SUA group still had higher arrhythmia risk than those in the middle SUA group (adjusted OR: 2.36, 95%CI: 1.26～4.39) and in the low SUA group (adjusted OR: 1.80, 95%CI: 1.11～2.90). There was no significant difference in arrhythmia risk in comparing the middle SUA group with the low SUA group (OR: 0.84, 95%CI: 0.55～1.30). Conclusion High SUA level is independently related to arrhythmia in women aged above 50 years in China. Arrhythmia risk will rise when SUA rises.

　　【Key words】 Middle- and old-aged women;Serum uric acid (SUA ); Arrhythmia