·糖尿病与代谢综合征·

　　血清Apelin水平与代谢综合征患者代谢指标相关性观察

　　孙桂丽 黎英荣 夏宁

　　【摘要】 目的 探讨MS患者血清Apelin与血糖、血压的关系。 方法 将132例研究对象分为MS组69例和糖调节正常(NGR)组63例;MS组再分为T2DM的MS(MS1)组35例和IGR的MS(MS2)组34例，NGR组按BMI分为超重/肥胖组33例与正常对照(NC)组30名。计算BMI，测定空腹Apelin、血糖、血压、血脂、FIns。 结果 MS组Apelin、FIns、ln(HOMA-IR)、SBP均高于NGR组(P<0.05)。FPG、SBP和BMI是Apelin的独立相关因素(r2分别为0.429、0.315、0.253， P均<0.01)。 结论 MS患者血压异常与Apelin升高密切相关，可能是由于肥胖伴糖脂代谢紊乱导致IR加重所致。

　　【关键词】 Apelin;代谢综合征;高血压;糖尿病，2型;胰岛素抵抗

Relationship between the serum Apelin level and hypertension in metabolic syndrome SUN Gui-li, LI Ying-rong, XIA Ning. Department of Endocrinology, the Third Affiliated Hospital of Guangxi Medical University, Nanning 530031, China

Corresponding author: LI Ying-rong, E-mail: liyingrong70@sina.com

　　【Abstract】 Objective To investigate the relationship of the serum apelin level with blood glucose and hypertension in patients with metabolic syndrome (MS). Methods The 132 subjects were given the oral glucose tolerance test, then they were divided into MS group, 69 patients in it, and normal glucose regulation (NGR) group, 63 subjects in it. The former was subdivided into diagnosed T2DM (MS1) group (35 cases) and impaired glucose tolerance (MS2) group (34 cases), while the latter was subdivided into overweight/obesity group (33 cases) and normal control (NC) group (30 cases) according to BMI. The fasting serum apelin was measured by ELISA. Meanwhile, the FIns, blood pressure, blood glucose, and lipid profile were also measured, and BMI calculated. Results The level of apelin, FIns, ln (HOMA-IR), and SBP in the MS group was significantly higher than in the NGR group (all P<0.05). In a multiple step-wise regression analysis, the finding was that FPG, SBP, and BMI were the independent factors related to apelin (r2=0.429, r2=0.315, r2=0.253, all P<0.01). Conclusion The increased serum apelin level is closely related to hypertension of MS patients. It may be the result of the increased insulin resistance caused by obesity accompanied with glycolipide metabolic disorders.

　　【Key words】Apelin; Metabolic syndrome (MS); Hypertension; Diabetes mellitus, type 2; Insulin resistance (IR)