·糖尿病临床研究·

　　IFG、IGT、IFG+IGT患者血清高敏C反应蛋白、胰岛素抵抗指数变化的临床研究

　　赵冬 王旭红

　　【摘要】　目的　探讨血清高敏C-反应蛋白(hsC-RP)和胰岛素抵抗指数(HOMA-IR)在IFG与IGT、IFG+IGT患者中的变化及相关性研究。方法　检测上述三类患者hsC-RP并通过FIns、FPG计算HOMA-IR，同时以颈动脉内膜-中层厚度(IMT)反应动脉粥样硬化程度,并对结果进行相关性分析。结果　IFG、IGT和IFG+IGT组FIns、HOMA-IR均比正常对照(NC)组增高 (P<0.05)。IGT、IFG+IGT组hsC-RP与NC组比较升高(P<0.05) 。HOMA-IR与hsC-RP呈正相关(r=0.48 P<0.01), hsC-RP与IMT呈正相关(r=0.42 P<0.05)。结论 慢性炎症与IR、动脉粥样硬化密切相关,hsC-RP升高是T2DM发生的预测因子，也是动脉硬化的危险因素。

　　【关键词】　空腹血糖受损;糖耐量减低;高敏C-反应蛋白; 胰岛素抵抗指数

Analysis on the variations of the serum high-sensitivity C-reactive protein and insulin resistance index in the IFG, IGT, IFG+IGT patients ZHAO Dong, WANG Xu-hong. Department of Endocrinology, The Luhe Teaching Hospital of Capital Medical University, BeiJing 101149, China

　　【Abstract】Objective To investigate the changes of serum high-sensitivity c-reactive protein (hsC-RP) and insulin resistance index (HOMA-IR) in the patients with impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or IFG+IGT and to study the correlations among them. Methods The detection of serum hsC-RP was done for the patients with IFG, IGT, or IFG+IGT and the HOMA-IR was calculated with the levels of fasting insulin (FIns) and fasting plasma glucose (FPG). The carotid intima-media thickness (IMT) was used to show the severity of atherosclerosis, and the result of which was applied for the analysis of their correlations. Results In the IFG, IGT, and IFG+IGT groups, the levels of FIns and HOMA-IR were higher than those in the normal control group (P<0.05). Compared with the normal control group, the level of hsC-RP was higher in the IGT and IFG+IGT groups (P<0.05). The level of HOMA-IR was positively correlated with hsC-RP (r=0.48, P<0.01), while the level of hsC-RP was positively correlated with IMT (r=0.42, P<0.05). Conclusion Chronic inflammation is closely related to the insulin resistance (IR) and atherosclerosis. The higher hsC-RP is a predictor of onset of T2DM and a risk factor for atherosclerosis as well.

　　【Key words】 Impaired fasting glucose (OFG); Impaired glucose tolerance (IGT); High-sensitivity C-reactive protein (hsC-RP); Insulin resistance index (HOMA-IR)