【摘要】 目的 分析T2DM发生恶性肿瘤的风险因素。方法 回顾性分析886例T2DM患者的临床资料，分析其发生恶性肿瘤的风险因素。结果 高龄、男性、心血管疾病、病程长、胰岛素治疗、吸烟、饮酒患者发生恶性肿瘤的OR(95%CI)分别为2.651(1.126～6.534)、2.362(1.116～8.884)、5.228(2.664～11.829)、4.382(2.883～9.235)、2.491(1.223～7.534)、1.911(1.022～3.834)、2.388(1.266～5.626)，其工作特征(ROC)曲线下面积分别是0.861、0.796、0.930、0.918、0.834、0.782、0.824。结论 高龄、男性、心血管疾病、病程长、胰岛素治疗、吸烟、饮酒是T2DM患者发生恶性肿瘤的风险因素。

　　【关键词】糖尿病，2型;恶性肿瘤;风险因素

　　Analysis on the risk factors of malignant tumor in T2DM patients XIAO Li-jun, MIAO Heng, ZHU Qun, et al. Department of Endocrinology, The Second Hospital Affiliated to Nanjing Medical University, Nanjing 210003,China

　　Corresponding author: MIAO Heng, E-mail: miaoheng-2011@163.com

　　【Abstract】 Objective To analyze the risk factors of malignant tumor in T2DM patients. Methods In this retrospective study, the clinical data of 886 primary T2DM patients were analyzed for confirming the risk factors of malignant tumor in T2DM patients. Results The OR(95%CI ) of senility, male, cardiovascular disease, long diabetes duration, insulin therapy, smoking, and alcohol drinking in patients with malignant tumor were 2.651 (1.126～6.534), 2.362 (1.116～8.884), 5.228 (2.664～11.829), 4.382 (2.883～9.235), 2.491 (1.223～7.534), 1.911 (1.022～3.834), and 2.388 (1.266～5.626) respectively, and the area under the curve was respectively 0.861, 0.796, 0.930, 0.918, 0.834, 0.782, and 0.824. Conclusion The elderly, male, cardiovascular disease, long diabetes duration, insulin treatment, smoking, and alcohol drinking are the risk factors of malignant tumor in T2DM patients.

　　【Key words】 Diabetes mellitus, type 2; Malignant tumor; Risk factors