【摘要】 目的 探讨不同振动阈值(VPT)危险分度的T2DM患者临床特点。方法 采用Bio-thesiometer测定T2DM患者下肢的VPT。根据VPT的结果将患者分为低风险组(0～-15V)、中度风险组(16～-25V)和重度风险组(>25V)，并探讨不同VPT风险组的临床特点和构成比，以及不同VPT危险分度和病程的关系。结果 VPT中、重度风险组的年龄、HbA1c和病程高于低度风险组(P<0.05);VPT中度受损占26.2%，重度受损占9.2%;中、重度风险组存在明显血脂代谢紊乱;HOMA-β中重度风险组明显低于低风险组(P<0.05和P<0.01)。 结论 T2DM患者VPT受损与年龄、病程、HbA1c、HOMA-β和血脂密切相关。

　　【关键词】 振动阈值;糖尿病，2型;糖尿病周围神经病变

　　Clinical characteristics of type 2 diabetes mellitus with different dangerous vibration perception threshold WANG Quan-sheng, YU Min. Department of Endocrinology, BenQ Medical Center, Nanjing Medical University, Nanjing 210019,China

　　【Abstract】Objective To explore the clinical characteristics of T2DM patients with different dangerous vibration threshold (VPT) values. Methods A Bio-thesiometer was adopted to measure the VPT of lower limbs of the T2DM patients. According to the result of measurements, the patients were divided into three groups: low risk group (0～-15V), moderate risk group (16～-25V), and high risk group (>25V). The clinical characteristics of patients with different risk degrees of VPT and the relationship between the different dangerous degrees and diabetes course were discussed. Results The age, HbA1c, and diabetes course of the patients in the moderate and severe risk groups were higher than those in the low risk group. The moderate impaired VPT occupied 26.2% and the severe impaired VPT occupied 9.2%. Obvious lipid metabolic disorders existed in the moderate and severe risk groups. HOMA-βin the moderate and severe risk groups was significantly lower than that in the low risk group (P<0.05, P<0.01). Conclusions The VPT impairment of T2DM patients was related with the age, HbA1c, HOMA-β, duration, and serum lipids.

　　【Key words】Vibration perception threshold (VPT); Diabetes mellitus, type 2; Diabetic peripheral neuropathy (DPN)