·药物研究动态·

　　【摘要】 随着疾病的进展，多数T2DM患者最终需要接受胰岛素治疗。目前，得到广泛公认的药物治疗途径是由口服降糖药经过单一胰岛素逐渐过渡至多次多种胰岛素注射。无论是在胰岛素起始治疗中还是在强化胰岛素治疗(基础+餐时胰岛素方案)中，地特胰岛素的疗效都得到了很好地证实，并且相对于其他基础胰岛素而言，具有低低血糖风险、增重少、个体血糖更加稳定的优势。

　　【关键词】地特胰岛素;糖尿病，2型;安全性;有效性

Once daily insulin detemir in the T2DM starting insulin therapy and intensive therapy DOU Jing-tao. Department of Endocrinology, People's Liberation Army General Hospital, Beijing 100853, China

　　【Summary】Most patients with T2DM would adopt insulin injection as the progression of disease. The widely accepted medication approach upgrades from oral anti-diabetic drugs through single insulin utilization to multiple insulin doses. The efficacy of insulin detemir has been thoroughly verified by abundant experiments, both in insulin initiation and intensive insulin therapy (basal-bolus insulin therapy). Compared with other basal insulin products, insulin detemir is with lower risk of inducing hypoglycaemia and weight gain, and less intraindividual variability.

　　【Key Words】Detemir; Diabetes mellitus, type 2; Safety; Efficacy