·糖尿病临床研究·

　　【摘要】 目的 观察三七对糖尿病肾病(DN)大鼠的治疗效果，探讨其作用机制，为糖尿病及DN的预防及治疗提供参考。 方法 予不同剂量三七治疗8周，观察其对STZ诱导的DN大鼠肾脏功能及结构的影响，观察各组血脂、血糖、体重、24 h尿蛋白定量、肾脏VEGF表达水平。 结果 三七不同剂量组血糖、TG、尿量、24 h尿蛋白定量及VEGF表达均有不同程度降低(P<0.05或P<0.01)，而体重、HDL-C均不同程度增加(P<0.05或P<0.01)。 结论 三七治疗DN大鼠有一定疗效，其机制可能与纠正相关代谢异常及改善组织缺血有关。

　　【关键词】 糖尿病微血管病变; 糖尿病肾病; 三七;血管内皮生长因子

Protective effect of Panax Preparations on microangiopathy in diabetic rats ZHAO Ling, KE Ting-yu, PENG Jia-rui,et al. VIP Department of Endocrinology, The 2nd Affiliated Hospital of Kunming Medical University, Kunming 650101, China

Corresponding author: KE Ting-yu, E-mail: ketingyu@hotmail.com

　　【Abstract】Objective To investigate the effect of panax preparations on experimental chronic kidney disease (CKD) in diabetes and its mechanism to provide reference for the treatment of diabetes and its microcomplications. Methods Diabetes was induced by streptozotocin (STZ) in rats. They were treated with panax preparations for 8 weeks. After treatment, the effect of panax preparations on functions and structures of kidney was observed, and the lipid and glucose levels in plasma, body weight, the 24h urinary protein excretion, and the expression of vascular endothelial growth factor (VEGF) of diabetic rats were determined for analysis. Results With different doses of panax notoginseng, the glucose and triglycerides (TG) levels, urine, 24h urinary protein excretion, and expression of VEGF of diabetic rats were all decreased (P<0.05 or P<0.01), while the body weight and high-density lipoprotein cholesterol (HDL-C) were increased (P<0.05 or P<0.01). The kidney structures and functions of diabetic rats were improved. Conclusions Panax notoginseng is effective for CKD. The possible mechanism may be related to the correction of the related metabolic disorders and improvement of ischemic state of the renal tissues.

　　【Key words】 Diabetic microangiopathy; Chronic kidney disease (CKD) in diabetes; Panax notoginseng; Vascular endothelial growth factor (VEGF)