·糖尿病临床研究·

　　【摘要】 目的 对T2DM伴胃动力液体排空功能障碍患者胃粘膜组织的胃泌素(GAS)、生长激素(GH)和神经降压素(NT)进行观察。 方法 纳入研究对象65例，分为T2DM(A)组和T2DM伴胃动力障碍(B)组，另选正常对照(NC)组。分别观察三组胃粘膜GAS、GH和NT的情况。 结果 A、B组GAS与NT水平均高于NC组(P均<0.05)。B组GAS和NT水平高于A组(P<0.05)。GAS、GH和NT是T2DM伴胃动力液体排空功能障碍的影响因素。 结论 GAS、GH和NT在糖尿病性胃动力障碍发病机制中起一定作用。

　　【关键词】 糖尿病，2型;胃动力障碍;胃泌素;生长激素;神经降压素

Observation on the gastrin, human growth hormone, and neurotensin levels in gastric mucosa of the patients with diabetic gastric motility disorders XUE Peng. Department of Emergency, PLA the 421st Hospital, Guangzhou 510318, China

　　【Abstract】Objective To observe the changes in the levels of gastrin (GAS), human growth hormone (GH), and neurotensin (NT) in gastric mucosa of the patients with diabetic gastric motility disorders. Methods The 65 T2DM cases were divided into 2 groups according to whether they were with or without gastric motility disorder: 32 cases in Group A without gastric motility disorder and 33 cases in Group B with gastric motility disorders. And 35 healthy volunteers were put into the control group. The observation on the different levels of GAS, hGH, and NTof the 3 groups was carried out for comparison. Results Compared with the control group, the levels of GAS and NT were all higher in Group A and B (P<0.05). The level of GAS in Group A was higher than in Group B (P<0.05). The levels of GAS, hGH, and NT were strongly related to diabetic gastric motility disorders. Conclusion GAS, hGH, and NT play very important roles in the pathogenesis of diabetic gastric motility disorders.

　　【Key Words】Diabetes Mellitus, type 2; Gastric motility disorders; Gastrin(GAS); Growth hormone (GH); Neurotensin (NT)