【摘要】 目的 探讨血清VitD水平与肥胖及代谢异常的关系。 方法 300例受试者，均为2009年1～12月间来我院进行健康体检的非体力劳动者。根据血清25羟维生素D水平将受试者分为对照组(NC组)和VitD下降组(HD)，对两组人体测量指数、血压、血脂、血糖水平及相关代谢疾病的患病情况进行比较。血清25羟维生素D水平采用ELISA法检测。 结果 HD组BMI、TC、TG、LDL-C均高于NC组(P均<0.05)，两组WC、SBP、DBP、FBG、HDL-C无明显差异。与NC组相比，HD组肥胖、腹型肥胖及高血压患病率也显著增高(P值分别为0.015，0.004，0.002)。 结论 血清VitD水平下降与肥胖及其代谢异常密切相关,血LDL-C是血VitD下降的独立危险因素。

　　【关键词 】 25-羟维生素D;VitD下降;肥胖;代谢异常

　　Relationship of serum vitamin D levels with obesity and metabolic abnormalities WANG Ying, YUAN Li, LU Chun-li, et al. Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

　　Corresponding author: Yuan Li, E-mail: yuanlil8cn@yahoo.com.cn

　　【Abstract】Objective To investigate the relationship of serum vitamin D with obesity and metabolic abnormalities. Methods A total of 300 adults who visited Wuhan Union Hospital for a general health checkup from January to December 2009 participated in the study. They were divided into hypovitaminosis D group and control group, 150 in each, according to their serum 25-(OH) D levels. The comparisons of somatometric index, blood pressure, plasma glucose, blood lipid, and the related metabolic diseases of the two groups were carried out. The serum 25-(OH)D concentration was detected with Enzyme-linked immunosorbent assay. Result In the hypovitaminosis D group, the levels of BMI, TC, TG, and LDL were all higher than those in the control group (all P<0.05). There was no significant difference in WC, SBP, DBP, FBG, and HDL between the two groups. Compared with the control group, the prevalence of obesity (P=0.015), central obesity (P=0.004) and hypertension (P=0.002) were higher in the hypovitaminosis D group. Conclusions Hypovitaminosis D is associated with obesity and metabolic abnormalities, and LDL-C is its independent risk factor.

　　【Key words】25-(OH)D; Hypovitaminosis D; Obesity; Metabolic abnormality