【摘要】目的 探讨不同糖耐量人群胰腺脂质沉积与IR的关系。方法 选择新诊断T2DM患者46例， IGR37例及健康对照(NC)者37名，接受上腹部CT平扫，用脾胰CT差值评估胰腺脂质沉积程度，计算稳态模式评估胰岛素抵抗指数(HOMA-IR)。结果 脾胰CT差值在NC、IGR和T2DM组内[(5.4±6.0) Hu、(8.2±6.1)Hu、15.5±7.0)Hu]递增，HOMA-IR也逐渐增加;多元线性回归分析表明，脾胰CT差值是HOMA-IR的独立相关因素(P<0.01)。结论 胰腺脂质沉积与IR相关，可能参与T2DM的发生发展。

　　【关键词】脂质沉积，胰腺;胰岛素抵抗;体层摄影术，螺旋计算机

　　Association of pancreatic lipid deposition with insulin resistance in people with different levels of glucose tolerance LIU Yan, KANG Dong-mei, YAO Hui, et al. Department of Senile Endocrinology, The Affiliated Provincial Hospital of Anhui Medical University, Hefei 230001, China

　　Corresponding author: KANG Dong-mei, E-mail: kangdongmei2006@sina.com

　　【Abstract】Objective To investigate the association between the degree of pancreatic lipid deposition and insulin resistance (IR) in people with different glucose tolerances. Methods The 46 newly diagnosed T2DM patients, 37 cases with impaired glucose regulation (IGR), and 37 healthy subjects (normal controls, NC) were selected (aged 67.1±6.8 years in average) for study. All subjects received upper abdominal CT scan and their Hounsfield units (Hu) were measured. Homeostasis model insulin resistance index (HOMA-IR) was calculated to evaluate the degree of their insulin resistance. Results The degree of pancreatic fat deposition in the NC, IGT, and T2DM groups increased progressively (5.4±6.0 Hu, 8.2±6.1 Hu , 15.5±7.0 Hu), the same trend as in HOMA-IR. Multiple regression analysis showed that the degree of pancreatic fat deposition was an independent relevant factor of HOMA-IR index (P<0.01). Conclusion The pancreatic fat deposition is closely related to insulin resistance and may be involved in the development of T2DM.

　　【Key words】Lipid deposition; Pancreas; Insulin resistance; Tomography; Spiral computed