【摘要】 胰岛β细胞受损是T2DM发病的关键因素。β细胞受损包括分泌功能受损和数量减少。新诊断T2DM后及早使用DPP-4抑制剂可有效保护β细胞，甚至逆转β细胞分泌功能的丧失，延缓糖尿病病程进展。

　　【关键词】β细胞;胰岛素;DPP-4抑制剂;糖尿病，2型

　　DPP-4 inhibitors：study progress of the preservation of pancreatic β-cells

　　ZOU da-jin, Department of Endocrinology, Changhai Hospital, Shanghai 200433, China

　　【summary】There is a progressive deterioration of β-cell function and mass in type 2 diabetes. DPP-4 inhibitor therapy started soon after diagnosis of type 2 diabetes could preserve and even reverse the progressive loss of insulin secretary capacity that is the fundamental cause of type 2 diabetes.

　　【key words】 βcell;Insulin;DPP-4 inhibitor;Diabetes type 2