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甘精胰岛素对2型糖尿病患者血浆胰岛素样生长因子-1、胰岛素样生长因子结合蛋白-1和血管内皮细胞生长因子的影响

来自:中国糖尿病资讯网  编辑:editor|点击数:|2012-09-24

  [摘要] 目的:探讨甘精胰岛素对T2DM患者血浆游离IGF-1(FIGF-1)、IGF结合蛋白-1(IGFBP-1)、VEGF的影响。方法:将患者随机分为甘精胰岛素治疗组和中性胰岛素(NPH)治疗组,比较两组在治疗0、3、6、12个月时血浆HbA1c、FIGF-1、IGFBP-1、VEGF浓度,及治疗期间发生低血糖次数。结果:甘精胰岛素治疗组HbA1c、VEGF在治疗后6、12个月与NPH治疗组差异均有统计学意义(P<0.05); IGFBP-1在治疗后3、6、12个月明显低于NPH治疗组(P<0.05);两组FIGF-1差异均无统计学意义(P>0.05);两组低血糖发生次数差异有统计学意义(P<0.05)。结论:与NPH比较,甘精胰岛素具有更好的血糖控制,增加患者血浆VEGF,降低IGFBP-1,对FIGF-1无影响。

  [关键词] 胰岛素, 长效; 胰岛素样生长因子Ⅰ; 胰岛素样生长因子结合蛋白质1; 血管内皮生长因子

  Effect of insulin glargine on plasma FIGF-1, IGFBP-1 and VEGF in type 2 diabetes RUAN Yi-sheng, WANG Yong, LU Ai-hua, et al. Department of Endocrinology, Chaohu the Second People\'s Hospital, Chaohu 238000, China

  Corresponding author: E-mail:

  【Abstract】objective To explore the effect of insulin glargine on the plasma free insulin-like growth factor-1 (FIGF-1), insulin-like growth factor binding protein-1 (IGFBP-1), and vascular epithelium growth factor (VEGF) in T2DM patients. Methods The patients were randomized into two groups, one group was treated with neutral protamine hagedom’s insulin (NPH) and the other treated with glargine insulin. The plasma concentration of HbA1C, IFGF-1, IGFBP-1, and VEGF in the 0, 3rd, 6th, and 12th month of treatment, and the frequency of hypoglycemia during treatment in the two groups were compared with each other respectively. Results HbA1C and VEGF in the glargine group were lower than those in the NPH group in the 6th and 12th month (P<0.05), and the difference was statistically significant. IGFBP-1 was significantly lower than that in the NPH group in the 3rd, 6th, and 12th month (P<0.05). The difference of FIGF-1 in the two groups was not significant in statistics (P>0.05). The difference of incidence of hypoglycemia was significant in statistics in the two groups (P<0.05). Conclusion Compared with NPH, insulin glargine has a better function in blood glucose control, increase of plasma VEGF, and decrease of IGFBP-1, without effect on FIGF-1.

  【Key words】 Insulin; Long-acting; Insulin-like growth factor-1 (FIGF-1); Insulin-like growth factor binding protein-1 (IGFBP-1); Vascular endothelium growth factor (VEGF)

上一篇:地特胰岛素联合阿卡波糖治疗口服降糖药失效的老年2型糖尿病的有效性和安全性 下一篇:清华大学第一附属医院2008至2010年胰岛素应用情况的分析