《中国糖尿病杂志》官方网站

20

您的位置:首页 > 中国糖尿病杂志 > 2012年 > 8期

2型糖尿病患者血浆Omentin-1水平与颈动脉粥样硬化的关系

来自:中国糖尿病资讯网  编辑:editor|点击数:|2012-09-24

  【摘要】 目的 探讨T2DM患者血浆网膜素-1 (Omentin-1)与颈动脉粥样硬化的关系,探讨其在T2DM颈动脉粥样硬化及大血管病变中的作用。 方法 62例T2DM患者,根据颈动脉内膜中层厚度(IMT)分为AS组和非AS组,同期选择我院健康体检者28名作为NC组,采用ELISA测定血浆Omentin-1水平,并分析血浆Omentin-1与BMI、血糖、血脂、高敏C反应蛋白(hsC-RP)、胰岛素抵抗指数(HOMA-IR)等相关代谢指标的关系。 结果 AS组与非AS组血浆Omentin-1水平均低于NC组(14.90±6.27 vs 18.83±7.91 vs 24.80±9.15 ng/ml, P均<0.01);AS组血浆Omentin-1水平显著低于非AS组 (P<0.01)。T2DM患者血浆Omentin-1与WHR、BMI、肝细胞生长因子(HGF)、hsC-RP、IMT、FPG、HOMA-IR、HbA1c呈负相关,与HDL-C呈正相关。HOMA-IR、BMI和IMT为影响T2DM患者血浆Omentin-1的独立相关因素。HOMA-IR、病程、hsC-RP和Omentin-1是影响T2DM患者IMT的独立相关因素。 结论 血浆Omentin-1与T2DM患者早期动脉粥样硬化密切相关,可能在T2DM颈动脉粥样硬化及大血管病变的发生发展中起着重要作用。

  【关键词】网膜素-1;糖尿病,2型;颈动脉粥样硬化

  Association between plasma omentin-1 and carotid atherosclerosis in patients with type 2 diabetes LUO Sujuan, LONG Lijuan, ZHAO Gang, et al. Department of Internal Medicine, Wushan People’s Hospital, Chongqing 404700, China

  Corresponding author: LUO Su-juan, Email: luosujuan2@126.com

  【Abstract】 Objective To investigate the association of plasma omentin-1 with carotid atherosclerosis in type 2 diabetic patients and to explore its roles in carotid atherosclerosis and macroangiopathy of type 2 diabetes mellitus. Methods Sixty-two patients with type 2 diabetes mellitus were divided into atherosclerosis (AS) group and non-AS group according to the intima-media thickness (IMT) of the carotid artery, and meanwhile choose 28 people coming for health examination as the control group. The fasting plasma omentin-1 level was measured by enzyme-linked immunosorbent assay (ELISA). The association of plasma omentin-1 level with body mass index (BMI), blood glucose and lipids, high-sensitivity C-reactive protein (hsCRP), HOMA-insulin resistance index (HOMA-IR), and other metabolic parameters was also analyzed. Results The fasting plasma omentin-1 level in the AS and non-AS groups was lower than in the NC group (14.90±6.27 vs 18.83±7.91 vs 24.80±9.15ng/ml, P<0.01), and it was lower in the AS group than in the non-AS group (P<0.01). The fasting plasma omentin-1 level was correlated negatively with waist hip ratio (WHR), BMI, hepatocyte growth factor (HGF), hsC-RP, IMT, fasting blood glucose (FPG), HOMA-IR, and hemoglobin A1c (HbA1c), and positively with high density lipoprotein cholesterol (HDL-C). HOMA-IR, BMI, and IMT were the independent related factors in influencing the plasma omentin-1 level of T2DM patients. HOMA-IR, course of disease, hsC-RP, and omentin-1 were the independent related factors in influencing the IMT of the carotid artery of T2DM patients. Conclusion The plasma omentin-1 level is closely correlated with the premature atherosclerosis in T2DM patients, and it may play an important role in the occurrence and development of carotid atherosclerosis and macroangiopathy in T2DM.

  【Key words】Omentin-1; Diabetes mellitus, type 2; Carotid atherosclerosis

上一篇:2型糖尿病患者慢性血糖波动对冠脉病变严重程度影响的相关研究 下一篇:地特胰岛素联合阿卡波糖治疗口服降糖药失效的老年2型糖尿病的有效性和安全性