糖尿病临床研究

　　【摘要】目的 探讨影响T2DM患者颈动脉内-中膜厚度(IMT)的相关因素。方法 比较正常糖耐量(NGT)与T2DM两组间IMT、年龄、BMI、血压、FPG、2 hPG 、血脂、C-RP、胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-IS)等指标的差异。结果T2DM患者颈动脉IMT高于NGT人群(P<0.01)，BMI、SBP、FPG、C-RP、HbA1c、HOMA-IR与T2DM患者颈动脉IMT呈正相关。结论T2DM患者中BMI、SBP、FPG、HbA1c、C-RP、HOMA-IR可能是颈动脉IMT增厚的主要危险因素。

　　【关键词】糖尿病, 2型;葡糖耐量试验;颈动脉内-中膜厚度

　　Analysis on related factors of carotid intima-media thickness in T2DM patients LI Hong-mei, ZHANG Jun, ZHANG Xue-bing. Department of Endocrinology and Metabolism, China Meitan General Hospital, Beijing100028, China

　　【Abstract】 Objective To investigate the related factors of carotid intima-media thickness (IMT) in T2DM patients. Methods Forty normal glucose tolerance (NGT) subjects and 40 T2DM patients were enrolled in the research. The comparison between the two groups in IMT, age, BMI, blood pressure, FPG, 2 hPG, blood lipid, C-RP, HOMA-IR, and HOMA-IS was carried out for analysis. Results The carotid IMT was significantly higher in T2DM patients than in NGT subjects (P<0.01). The BMI, SBP, FPG, C-RP, HbA1c, and insulin resistance were positively related with carotid IMT in T2DM patients. Conclusion The BMI, SBP, FPG, HbA1c, CRP, and HOMA-IR may be the main risk factors that affect carotid IMT in T2DM patients.

　　【Key Words】 Diabetes mellitus, type 2; Glucose tolerance test; Carotid intima-media thickness