·糖尿病心血管病·

　　洪旭 陈海平 于恒池

　　作者单位：100050北京，首都医科大学附属北京友谊医院内分泌科(洪旭、于恒池)，老年病科(陈海平)

　　通讯作者：陈海平，E-mail: chp3@sina.com

　　【摘要】 目的 观察2型糖尿病患者血清炎症因子水平的变化，探讨炎症因子对2型糖尿病尤其老年患者合并心脑血管病变的影响。 方法 103例2型糖尿病患者按年龄及是否合并心脑血管病变分别分组。用自动生化分析仪测定所有患者血清高敏C反应蛋白(hsC-RP)、FBG、HbA1c、TC、TG、LDL-C水平，用ELISA 方法 测定血清白介素6(IL-6)和肿瘤坏死因子α(TNF-α)水平。 结果 (1)2型糖尿病患者年龄≥65岁者，血清hsC-RP、TNF-α、IL-6水平均高于年龄<65岁者(P<0.01)。(2)合并心脑血管病变者，血清hsC-RP水平较高于无心脑血管病变者(P<0.05)。年龄≥65岁中合并心脑血管病变者，血清hsC-RP水平高于无心脑血管病变者(P<0.05)。(3)血清hsC-RP水平与年龄和血清TG水平呈正相关(r=0.257，P<0.01;r=0.220，P<0.01)。影响hsC-RP的因素主要为年龄，回归方程为y(hsC-RP)=2.407+0.100年龄。(4)2型糖尿病中≥65岁者合并心脑血管病变的发生率高于<65岁者(P<0.01)。 结论 hsC-RP与大血管病变相关，但IL-6和TNF-α与大血管病变无明显相关性;年龄增长是血清hsC-RP水平升高的主要影响因素。

　　【关键词】糖尿病，2型;心脑血管病变;高敏C反应蛋白;肿瘤坏死因子α;白介素6

　　doi:10.3969/j.issn.1006-6187.2011.08.004

　　The level of the serum inflammatory factors and their relationship with cardiocerebral vascular diseases in elderly patients with type 2 diabetes mellitus

　　HONG Xu, CHEN Shu-jun, CHEN Hai-ping. Department of Endocrinology, Beijing Friendship Hospital, Capital Medical University , Beijing 100050，China

　　Corresponding author: CHEN Hai-ping, E-mail: chp3@sina.com

　　【Abstract】 Objective To investigate the serum levels of the inflammatory factors and their relationship with cardiocerebral vascular disease in type 2 diabetes mellitus. Methods The 103 patients with type 2 diabetes mellitus were divided into groups with and without cardiocerebral vascular disease and groups at age of <65 and ≥65 years. We detected the levels of serum hsC-RP, fasting blood glucose(FBG), glycosylated hemoglobin(GHbA1c), cholesterol total(TC), triglyceride(TG), low density lipoprotein-C(LDL-C), serum TNF-α and IL-6. Results (1)The levels of serum hsC-RP, TNF-α and IL-6 were higher in patients of age≥65 years than of age<65 years (P=0.003，P=0.001，P=0.007).(2)The level of serum hsC-RP was higher in patients with cardiocerebral vascular disease (CCVD) than without CCVD(P=0.015). The level of serum hsC-RP was higher in patients with CCVD and at age of ≥65 years than in patients without CCVD(P=0.040). (3)Serum hsC-RP was positively correlated with age and serum TG(r=0.257，P=0.000;r=0.220，P=0.003). The influencing factor for hsC-RP was age. (4)The incidence rate of CCVD in type 2 diabetes mellitus patients at age≥65 years was higher than patients at age<65 years(P=0.000). Conclusion The serum hsC-RP is positively correlated with cardiocerebral vascular disease in T2DM，but IL-6 and TNF-α are not significantly associated with CCVD. And age is a main influencing factor for hsC-RP.

　　【Key words】Diabetes mellitus, type 2; Cardiocerebral vascular disease; CRP; TNF-α; IL-6