·糖尿病临床流行病学·

　　陈冯梅 郭志荣 胡晓抒 武鸣 周慧

　　基金项目：卫生部科学研究基金(WKJ 2004-2-014)

　　作者单位：215009苏州卫生职业技术学院(陈冯梅);苏州大学(郭志荣);江苏省卫生厅(胡晓抒);江苏省疾病预防与控制中心(武鸣);苏州工业园区疾病预防与控制中心(周慧)

　　通讯作者：郭志荣，E-mail: guozhirong28@163.com

　　【摘要】 目的 通过前瞻性研究比较non-HDL-C、LDL-C在代谢综合征(MS)人群、非MS人群中与2型糖尿病(T2DM)发病的关系。 方法 将各血脂指标按水平三等分，以不患MS且血脂水平处于第一等分组的人群为对照组，比较MS、非MS人群各血脂水平与T2DM发病的关系。 结果 MS人群的血脂水平明显高于非MS人群。非MS人群中，TG、non-HDL-C、LDL-C水平在第三等分组时发生T2DM的风险最高。MS人群发生T2DM的风险均高于同血脂水平的非MS人群，但第三等分组发生T2DM的相对危险度(RR值)并没有增加。 结论 MS人群发生T2DM的风险高于非MS人群，但其发生T2DM的风险并没有随血脂水平的增高而增加。而非MS人群中，non-HDL-C、LDL-C在第三等分组发生T2DM的风险最高，且non-HDL-C的预测作用强于LDL-C。

　　【关键词】代谢综合征;糖尿病，2型;非高密度脂蛋白胆固醇

　　doi:10.3969/j.issn.1006-6187.2011.08.002

　　The effects of the different blood lipid components on the T2DM occurrence in metabolic syndrome (MS) versus non-MS patients

　　CHEN Feng-mei，GUO Zhi-rong，HU Xiao-shu,et al. Suzhou Medical Technology College, Suzhou 215009,China

　　Corresponding author: GUO Zhi-rong,E-mail:guozhirong28@163.com

　　【Abstract】 Objective The effects of the different blood lipid components on the T2DM occurrence in metabolic syndrome (MS) versus non-MS patients. Methods The risk ratio (RR) of type 2 diabetes occurrence was assessed based on different blood lipid componet effects in MS versus non-MS patients. Results Patients with MS had a higher T2DM RR than those without MS. In a multivariate model, T2DM risk in MS population didn’t increase with increasing lipid. While in non-MS population, the third trisection of non-HDL-C, LDL-C had the highest RRs of 1.69[1.06-2.68] in non-HDL-C of the third trisection, and 1.64[1.02-2.63]in LDL-C of the third trisection (all P<0.05). Conclusions Non-HDL is a stronger predictor for T2DM occurrence among the non-MS population than LDL, and it should be given more consideration in the clinical approach to risk reduction among non-MS populations.

　　【Key words】Metabolic syndrome;Diabetes mellitus, type 2;Non-HDL cholesterol