作者单位：100017北京，中国人民解放军第305医院内分泌科(黄海、祝开思、王平)，全军老年病实验室中心(张世俊)

通讯作者：祝开思，E-mail:zhukaisi@sina.com

新诊断的2型糖尿病患者胰岛素强化治疗前后

氧化应激水平的变化

黄海祝开思王平张世俊

【摘要】目的评价新诊断的2型糖尿病(T2DM)患者胰岛素强化治疗前后氧化应激水平的变化。方法30例新诊断的T2DM患者采用胰岛素泵强化治疗，治疗前后进行超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)水平测定。结果胰岛素泵强化治疗后，患者血浆中的SOD、GSH-Px水平明显上升(P<0.01)、MDA水平明显下降(P<0.01)。结论新诊断的T2DM患者胰岛素强化治疗后氧化应激水平明显降低。

【关键词】糖尿病，2型;胰岛素泵;氧化应激

doi:10.3969/j.issn.1006-6187.2011.05.006

The effect of continuous subcutaneous insulin infusion on oxidative stress level in newly diagnosed type 2 diabetic patientsHUANG Hai, ZHU Kai-si, WANG Ping, et al. Department of Endocrinology, PLA 305 Hospital, Beijing 100017, China

Corresponding author: ZHU Kai-si, E-mail:zhukaisi@sina.com

【Abstract】ObjectiveTo evaluate the effect of continuous subcutaneous insulin infusion (CSII) on oxidative stress level in newly diagnosed T2DM patients.Methods30 newly diagnosed T2DM patients were treated with continuous subcutaneous insulin infusion.The levels of SOD,GSH-Px and MDA were measured after insulin pump therapy.ResultsAfter the treatment, SOD and GSH-Px had more significant improvement. Otherwise, MDA was significantly decreased (P<0.01).ConclusionsOxidative stress level of newly diagnosed T2DM patients is significantly decreased after continuous subcutaneous insulin infusion treatment.

【Key words】Diabetes mellitus, type 2; Insulin pump; Oxidative stress