来自:中国糖尿病资讯网 编辑:admin|点击数:|2011-10-20
·糖尿病性肾脏疾病·
吴东红 程瑶 徐滨华 胡涛 李征寒
基金项目:哈尔滨市科技攻关计划项目(2007AA3CS084-6)
作者单位:150010哈尔滨市第一医院
【摘要】 目的 探讨血浆内皮素(ET)和同型半胱氨酸(Hcy)与糖尿病性肾脏疾病(DKD)的关系。 方法 测定116例糖尿病(DM)患者和100名正常对照者(NC组)血浆ET、Hcy及尿白蛋白排泄率(UAER)。 结果 DM无肾病组血浆ET和Hcy含量均高于NC组(P<0.05);微量白蛋白尿组与临床白蛋白尿组血浆ET和Hcy均与NC组比较有统计学差异(P<0.05)。相关性分析显示,临床白蛋白尿组血浆ET和Hcy与UAER呈正相关。 结论 血浆ET和Hcy的上升,可能反映DKD的进展。
【关键词】内皮素;同型半胱氨酸;尿白蛋白
doi:10.3969/j.issn.1006-6187.2011.03.006
Association of plasma endothelin and homocysteine with diabetic kidney disease (DKD)
WU Dong-hong,CHENG Yao,XU Bin-hua,et al.Department of Endocrinology,the First Hospital of Harbin,Harbin 150010, China
【Abstract】 Objective To investigate the relationship of the plasma endothelin and homocysteine with renal injury in diabetes. Methods The plasma endothelin(ET),homocysteine(Hcy) and urinary albumin excretion rate (UAER)were assayed in 116 patients with diabetes and 100 healthy volunteers. Results Both plasma Hcy and ET were higher in MUAlb and CUAlb group than in NC and NUAlb group,and higher in NUAlb than in NC group (all P<0.05).Plasma ET and Hcy were positively correlated with UAER (all P<0.05).Plasma ET was positively correlated with plasma Hcy. Conclusions The high level of plasma endothelin and homocysteine may correlated with a progression of DKD in patients with diabetes.
【Key words】Endothelin;Homocysteine ;Urinary albumin
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