·药物研究动态·

　　姬秋和 、周岩

　　作者单位：710032西安，解放军第四军医大学西京医院内分泌代谢科(姬秋和);解放军第四五一医院内分泌科(周岩)

　　【提要】德谷胰岛素分子结构独特，在皮下注射部位形成多六聚体结构的药物储库，从而发挥超长药效(>24h)，是一种新型超长效胰岛素类似物。德谷胰岛素的药动学曲线平稳，药效学变异性小。临床研究结果显示德谷胰岛素能够有效的控制血糖，同时降低了治疗期间低血糖事件的发生。

　　【关键词】糖尿病;德谷胰岛素;超长效基础胰岛素类似物

　　doi:10.3969/j.issn.1006-6187.2011.12.021

　　Research progress of insulin degludec ——An ultra-long-acting basal insulin analogue JI Qiu-he, ZHOU Yan. Endocrinology and Metabolism Department， Fourth Military Medical University Xijing Hospital, Xi′an 710032, China

　　【Summary】Insulin degludec (IDeg) has unique molecular structure which could form multi-hexamers (drug depot) after subcutaneous injection, resulting in an ultra-long effect (half life of IDeg>24h), a consistent and flat pharmacokinetic profile at steady state, and the consistently low within-subject variability of pharmacodynamics. From the clinical trial results available, IDeg is safe with reduced rate of hypoglycemic events and is reliable with stable glycemic control.

　　【Key words】Diabetes, Insulin degludec, Ultra-long basal insulin analogue