作者单位：066000秦皇岛，河北医科大学附属秦皇岛市第一医院内分泌科 (刘博伟、陆强、刘俊茹、马春明、尹福在),检验科(王术艺)

　　通讯作者：尹福在,E-mail:yinfuzai62@sina.com

　　刘博伟 陆强 刘俊茹 马春明 王术艺尹福在

　　【摘要】 目的 探讨有T2DM家族史且BMI正常的青少年空腹血浆中Ghrelin水平的变化及相关影响因素。 方法 80名13~15岁BMI正常青少年，根据有无糖尿病家族史分为糖尿病家族史阳性组(FHD+)和糖尿病家族史阴性组(FHD-)。测量身高、体重及血压，检测FPG、血脂、空腹真胰岛素(FTI)及Ghrelin水平。 结果 FHD+组BMI、FPG、FTI和胰岛素抵抗指数(HOMA-IR)高于FHD-组(P<0.05)，空腹Ghrelin水平低于FHD-组(P<0.01)。Ghrelin与FPG(r=-0.456，P<0.01)，FTI(r=-0.183，P<0.05)和HOMA-IR (r=-0.237，P<0.01)呈负相关。以Ghrelin为因变量，行多元线性回归显示，FPG (β=-354.435, P<0.01)和FHD(β=-176.468, P<0.01)为独立危险因素。 结论 有T2DM家族史的BMI正常的青少年已存在空腹Ghrelin水平的降低，FPG的升高和糖尿病家族史可能是Ghrelin水平降低的相关因素。

　　【关键词】糖尿病，2型;家族史;Ghrelin;胰岛素抵抗;青少年

　　doi:10.3969/j.issn.1006-6187.2011.11.009

　　The influencing factors for serum ghrelin changes in non-obese adolescents with family history of type 2 diabetes. LIU Bo-wei, LU Qiang,LIU Jun-ru, et al. Department of Endocrinology, the First Hospital of Qinhuangdao, Hebei Medical Univesity, Qinhuangdao 066000,China

　　Corresponding author: YIN Fu-zai, E-mail:yinfuzai62@sina.com

　　【Abstract】 Objective To investigate the influencing factors of ghrelin in non-obese adolescents with family history of type 2 diabetes. Methods The study included 80 non-obese adolescents aged 13-15 years. 40 subjects had no family history of type 2 diabetes (FHD- group), and 40 subjects had a family history of type 2 diabetes (FHD+ group).Body height, weight and blood pressure were measured. Fasting plasma glucose(FPG), serum lipids, fasting true insulin(FTI) and ghrelin were assayed. Results FHD+ group had significantly higher levels of body mass index(BMI),FPG,FTI and HOMA-IR than did FHD- group (P<0.05).FHD+ group had significantly lower level of ghrelin than did FHD- group (P<0.01). Ghrelin showed negative correlation with FPG(r =-0.456，P=0.000)，FTI(r =-0.183，P=0.021) and HOMA-IR (r =-0.237，P=0.003). In multiple linear regression analysis, FPG (β=-354.435, P=0.000) and FHD(β=-176.468, P=0.006) were significantly independent relative foctors for ghrelin. Conclusions The lower ghrelin level is found in non-obese adolescents with family history of type 2 diabetes. Elevated FPG and FHD may be the relative factors for lower ghrelin level.

　　【Key words】 Diabletes,type 2;Family history;Ghrelin;Insulin resistance;Adolescent·糖尿病与心血管病·