·HbA1c的应用·

　　关美萍 薛耀明 谢翠华 符霞军 李际敏 陈晨 张洋 王海明

　　作者单位：510515广州，南方医科大学南方医院内分泌代谢科

　　【摘要】 目的 探讨HbA1c作为糖尿病诊断标准的临床应用价值。 方法 对43例个体行75g OGTT和HbA1c检测。 结果 HbA1c≥6.0%和≥6.5%分别作为诊断糖调节异常和糖尿病的标准，其灵敏度分别为70.59%和50.00%，特异度为88.89%和77.78%。 结论 以HbA1c≥6.0%作为糖调节异常的诊断标准具有较好的临床应用价值，但以HbA1c≥6.5%作为糖尿病诊断标准的应用价值并不满意。

　　【关键词】糖化血红蛋白;糖尿病;诊断标准

　　doi:10.3969/j.issn.1006-6187.2011.11.006

　　Investigation of diagnostic value of HbA1c for diabetes mellitusGUAN Mei-ping, XUE Yao-ming, XIE Cui-hua, et al. Department of Endocrinology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China

　　【Abstract】  Objective   Invastigation of the diagnostic values of glycated hemoglobin A1c (HbA1c) versus oral glucose tolerance test (OGTT) for diabetes mellitus (DM).   Methods   75g-OGTT and HbA1c data were analyzed in 43 participants.   Results   The sensitivities (Se) of HbA1c for the diagnosis of impaired glucose regulation (IGR) and DM were 70.59% and 50.00%, the specificities (Sp) of HbA1c for IGR and DM diagosis were 88.89% and 77.78%, respectively. Conclusions   The value of HbA1c≥6.0% for the diagosis of IGR is very well, while the value of HbA1c≥6.5% for the diagnosis of DM is not satisfied.

　　【Key Words】Glycated hemoglobin ; Diabetes mellitus; Diagnostic criteria