·糖尿病性肾脏疾病·

　　贾安奎 刘彦轩 许光霞 王国戗

　　作者单位：453100河南新乡，新乡医学院附属第一医院检验科(贾安奎、王国戗)，遗传科(刘彦轩)，泌尿外科(许光霞)

　　【摘要】 目的 探讨糖尿病患者尿单核细胞趋化蛋白1 (MCP-1) 和血细胞间黏附分子1 (ICAM-1)水平与糖尿病肾病的发生发展及炎症反应的关系。 方法 将90例糖尿病患者按尿白蛋白排泄率(UAER)分为正常白蛋白尿(NA)组、微量白蛋白尿(MA)组、临床白蛋白尿(CA)组，分别测定血、尿MCP-1与血sICAM-1和高敏C反应蛋白(hsC-RP)，并与30名健康对照组(NC)比较。 结果 NC、NA、MA、CA 组间的血MCP-1水平差异无统计学意义(P>0.05)，尿MCP-1及血sICAM-1水平逐渐升高，差异有统计学意义(P<0.05或P<0.01);尿MCP-1及血sICAM-1水平与UAER均呈正相关(r=0.891,P<0.01;r=0.583，P<0.01);尿MCP-1及血sICAM-1水平与血hsC-RP均呈正相关(r=0.723,P<0.01;r=0.625,P<0.01)。 结论 尿MCP-1及血sICAM-1水平与糖尿病肾病炎症反应程度有一定关系,可作为肾脏损害程度及其发生发展的判断指标。

　　【关键词】糖尿病肾病;单核细胞趋化蛋白1;细胞间黏附分子1

　　doi:10.3969/j.issn.1006-6187.2011.10.007

　　Relationship of urine monocyte chemoattractant protein-1 and serum intercellular adhesion molecule-1 with inflammatory response in diabetic nephropathy

　　of T2DM patients

　　JIA An-kui, LIU Yan-xuan,XU Guang-xia，et al.The Affiliated First Hospital of Xinxiang Medical University, He′nan 453100，China

　　【Abstract】 Objective To study the correlation of monocyte chemoattractant protein-1(MCP-1)and serum intercellular adhesion molecule-1 (sICAM-1) with inflammatory response in diabetic nephropathy of T2DM patients.  Method   90 diabetes mellitus patients were divided into three subgroups(n=30, each): normo-albuminuria(NA),micro-albuminuria(MA) and clinical albuminuria(CA).The MCP-1, sICAM-1 and hsC-RP were determined by ELISA respectively ,which were compared with 30 normal controls (NC).   Results  The levels of serum MCP-1 did not differ among groups of NC, NA, MA and CA(P>0.05).The levels of urine MCP-1 and serum sICAM-1 were progressively higher in CA group than in MA(P<0.05 or P<0.01), in MA than in NA (P<0.01), and in NA than in NC (P<0.01).The urine MCP-1 and serum sICAM-1 correlated positively with UAER  .891,P<0.01;r=0.583，P<0.01)and with serum hsC-RP (r=0.723,P<0.01;r=0.625,P<0.01).   Conclusion  The urine MCP-1 and serum sICAM-1 are associated with kidney damage and inflammatory response,and might serve as clues to potential predictors for the development of diabetic nephropathy.

　　【Key words】Diabetic nephropathy ; Monocyte chemoattractant protein-1; Intercellular adhesion molecule-1