【提要】CD36是一种跨膜糖蛋白，属于清道夫受体家族。其在体内分布广泛，可与多种配体结合发挥生理及病理作用。CD36同时作为一种脂肪酸转运蛋白参与脂肪代谢，其在肝细胞及脂肪细胞表达的变化是非酒精性脂肪性肝病（NAFLD）发生的关键环节。本文将就CD36与NAFLD的关系及其在NAFLD中表达调控研究的近期成果进行综述。

【关键词】CD36；非酒精性脂肪性肝病；表达；调控；脂肪代谢

The relationship between CD36 and non-alcoholic fatty liver disease

YANG Ling, DI Fu-sheng. Department of Endocrinology, Tianjin Third Central Hospital, Tianjin 300170, China

Corresponding author: DI Fu-sheng, E-mail: difusheng@vip.163.com

【Summary】CD36 is a class of transmembrane glycoprotein, which belongs to the scavenger receptor family. It is distributed in various tissues. CD36 can play important roles in many physiological and pathological processes by binding to the ligands. As a fatty acid transporter protein, it is also involved in lipid metabolism. The abnormal expression of CD36 in hepatocytes and adipocytes is the key on the development of non-alcoholic fatty liver disease (NAFLD). In this article, we will review the newly studies to introduce the relationship between CD36 and NAFLD and the regulation mechanism of CD36.

【Key words】CD36; Non-alcoholic fatty liver disease; Expression; Regulation; Lipid metabolism