【提要】近年来，胰升血糖素样肽-1 (GLP-1)相关治疗因表现出降糖作用以外的心血管保护作用而成为研究热点。GLP-1可通过改善糖脂代谢、减轻体重、降低血压等作用控制冠心病的危险因素，还可直接作用于心血管系统，起到改善内皮功能、抑制动脉粥样硬化斑块形成、减轻缺血再灌注损伤及改善心功能的作用。

【关键词】胰升血糖素样肽-1；糖尿病，2型；冠心病

Protective effects of glucagon like peptide-1 related therapy on cardiovascular system  LU Ran, MA Xiao-wei, GUO Xiao-hui. Department of Endocrinology,Peking University First Hospital,Beijing 100034,China

【Summary】Accumulated evidences suggest that glucagon-like peptide 1 (GLP-1) related therapy bestows cardiovascular protective effects beyond its hypoglycemic effects. By controlling the risk factors of cardiovascular disease, improving endothelial function, inhibiting the formation of atherosclerotic lesions, reducing myocardial ischemia reperfusion injury and improving heart function, GLP-1 exerts both indirect and direct protective effects on cardiovascular system.

【Key words】Glucagon-like peptide-1（GLP-1）； Diabetes mellitus， type 2; Coronary heart disease(CHD)