【摘要】 目的 探讨1,5-脱水葡萄糖醇(1,5-AG)与T2DM患者UAlb水平相关性。 方法 收集住院T2DM患者411例，根据HbA1c水平分为≤7%组81例和>7%组330例，另根据24 hUAlb两组各分为<30 mg/24 h亚组及30～299 mg/24 h亚组，检测相关生化指标及1,5-AG水平。 结果 在HbA1c≤7%组中,30～299 mg/24 h亚组1,5-AG低于UAlb<30 mg/24 h亚组[17.3(12.34,23.83) vs 10.40(7.20,13.78)μg/ml,P<0.05];在HbA1c>7%组中,两亚组1,5-AG水平比较，差异无统计学意义[2.67(1.26,6.35) vs 2.44(1.22,5.30)μg/ml,P>0.05]。 结论 在HbA1c≤7%的T2DM患者中,1,5-AG可能是30mg/24 h≤UAlb<299 mg/24 h的相关因素。

　　【关键词】 1,5-脱水葡萄糖醇;糖尿病，2型;尿白蛋白。

　　Study on the correlation between 1,5-anhydroglucitol and Urinary Microalbuminuria in type 2 diabetic patients CHEN Ru-hong, WANG Yao, WANG Yu-rong et al. Department of Endocrinology, Nanjing Jiangbei People’s Hospital affiliated to Southeast University, Nanjing 210048, China

　　【Abstract】 Objective To investigate the correlation between the level of serum 1,5 - anhydroglucitol ( 1,5-AG) and UAlb in patients with T2DM. Methods 411 hospitalized patients with T2DM were recruited and divided into two groups according to the levels of HbA1c: ≤ 7% or >7%. Each group was divided into two subgroups according to the levels of 24hUAlb: UAlb<30 mg/24 h subgroup and 30～299 mg/24 h subgroup. HbA1c, serum 1,5-AG, UAlb and biochemical indexes were tested and compared. Results In HbA1C ≤ 7% group , 1,5-AG level in 30～299 mg/24 h subgroup was lower than in 30 mg/24 h subgroup [17.3(12.34,23.83) vs 10.40(7.20,13.78)μg/ml, P<0.05]; In HbA1c>7% group, there was no difference in the level of 1,5-AG between two subgroups [2.67(1.26,6.35) vs 2.44(1.22,5.30)μg/ml, P>0.05]. Conclusion In T2DM patients with HbA1c ≤7%, 1,5-AG may be the risk factor of increased urinary microalbumin.

　　【Key words】 1,5-anhydroglucitol(1,5-AG); Diabetes mellitus, type 2; Urinary albumin(UAlb)