·糖尿病临床研究·

　　【摘要】 目的 探讨T2DM患者血清C-P水平变化与微血管病变的关系。 方法 回顾性分析434例T2DM患者的临床资料，根据ΔC-P的三分位数由低到高分为ΔC-P1(≤2.2 ng/ml)、ΔC-P2(2.3～4.0 ng/ml)和ΔC-P3(≥4.1 ng/ml)。 结果 ΔC-P1组BMI、TG、FC-P水平较低，病程、HbA1c水平较高(P<0.05)。血清ΔC-P水平与BMI、TG水平呈正相关(P<0.05)，与DR、糖尿病慢性肾脏疾病(CKD)发病率、病程、HbA1c水平呈负相关(P<0.05)。随DR和CKD的进展，ΔC-P水平逐渐降低。Logistic多元回归分析显示，在校正相关因素后，较低水平的ΔC-P是发生微血管并发症的独立危险因素。 结论 血清ΔC-P水平是T2DM微血管并发症的独立相关因素。

　　【关键词】 糖尿病，2型;糖尿病慢性肾脏疾病;糖尿病视网膜病变;C肽

　　【Abstract】 Objective To evaluate the relationship between serum C-peptide (C-P) levels and microvascular complications in patients with T2DM. Methods Clinical data of 434 patients with T2DM were retrospectively analyzed. All subjects were divided into three groups based on ΔC-P (2hC-P-FC-P) tertiles: ΔC-P1(≤2.2 ng/ml), ΔC-P2(2.3～4.0 ng/ml) and ΔC-P3(≥4.1 ng/ml). Results Compared withΔC-P2 group andΔC-P3 group, the levels of BMI, TG, FC-P were lower, and the duration and HbAlc were higher in ΔC-P1 group. ΔC-P level was positively associated with BMI and TG(P<0.05), and negatively associated with the prevalence of DR and chronic kidney disease (CKD), duration of diabetes and HbA1c.ΔC-P levels gradually decreased with the progression of DR and CKD. Logistic regression analysis showed that lower ΔC-P level was the independent risk factor for microvascular complications after adjustment for related factors. Conclusion Serum ΔC-P level is an independent factor related to the development of microvasculr complications in T2DM.

　　【Key words】 Diabetes mellitus， type 2;Chronic kidney desease (CKD) in diabetes;Diabetic retinopathy (DR);C-peptide(C-P)