【摘要】 目的 探讨T2DM患者血清中性粒/淋巴比值(NLR)与DR的相关性。 方法 将128例T2DM患者分为增殖期糖尿病视网膜病变(PDR)者22例、非增殖期糖尿病视网膜病变(NPDR)者44例和单纯T2DM者62例。检测各组FPG、HbA1c、TC、TG和NLR等指标水平。 结果 Spearman相关性分析显示，DR与T2DM病程、SBP、DBP、FPG、HbA1c、TC、TG、LDL-C、NLR、CKD呈正相关(r=0.524、0.277、0.279、0.194、0.271、0.208、0.223、0.358、0.621、0.362，P<0.05或P<0.01)。Logistic多元回归分析结果显示，T2DM病程、NLR和CKD是DR的独立影响因素。 结论 NLR与DR存在相关性。

　　【关键词】中性粒/淋巴比值;糖尿病视网膜病变;糖尿病，2型

　　【Abstract】 Objective To explore the association between serum neutrophil-to-lymphocyte ratio (NLR) and DR in T2DM patients. Methods A total of 128 T2DM patients were recruited and divided into three groups: PDR group (n=22), NPDR group(n=44), and simple T2DM group(n=62). The levels of FPG, HbA1c, TC, TG and NLR were measured in each group. Results Spearman correlation analysis revealed that DR was positively correlated with T2DM duration, SBP, DBP, FPG, HbA1c, TC, TG, LDL-C, NLR, CKD (r=0.524, 0.277, 0.279, 0.194, 0.271, 0.208, 0.223, 0.358, 0.621, 0.362, P<0.05 or P<0.01). Logistic multiple regression analysis showed that, T2DM duration, NLR and CKD were independent risk factors for DR. Conclusion NLR level is associated with DR.

　　【Key words】Neutrophil-to-lymphocyte ratio (NLR);Diabetic retinopathy (DR);Diabetes mellitus，type 2