·糖尿病基础研究·

　　【摘要】 目的 分析血脂对T2DM大鼠神经病理性疼痛的相关危险因素。 方法 选取雌性清洁级Wistar大鼠分为非糖尿病标准饮食组(NdStd)、糖尿病高脂饮食疼痛组(DbHFP)、糖尿病高脂饮食非疼痛组(DbHFNP)，各10只。定期检测每组体重、血糖、TG、TC、HDL-C、LDL-C、50%疼痛阈值，评估血脂与疼痛的关系。 结果 线性相关分析显示，疼痛阈值与TG、LDL-C、血糖与呈负相关(OR=0.908、0.583、0.875，P<0.05)，与HDL-C呈正相关(OR=-0.913，P<0.05),而与TC和体重无相关性。 结论 糖尿病大鼠疼痛阈值与TG、LDL-C及血糖负相关，与HDL-C正相关。

　　【关键词】 糖尿病;神经病理性疼痛;血脂;危险因素

　　【Abstract】 Objective To explore the related risk factors for neuropathic pain in diabetic rats. Methods Female Wistar rats of clean grade were divided into three groups: Non diabetic standard diet (NdStd) group (n=10), diabetic high fat diet and pain (DbHFP) group (n=10), and diabetic high fat diet and no pain (DbHFNP) group (n=10).Body weight, blood sugar, TG, TC, HDL-C, LDL-C and 50% pain threshold were measured regularly to assess the relationship between blood lipids and pain. Results Linear correlation analysis showed that pain threshold was negatively correlated with TG, LDL-C and blood sugar (OR=0.908, 0.908, 0.908, P<0.05), and positively correlated with HDL-C (OR=0.913, P<0.05). And there was no association between TC and body weight. Conclusion Pain threshold of diabetic rats was negatively correlated with TG, LDL-C and blood sugar, and positively correlated with HDL-C.

　　【Key words】 Diabetes;Neuropathic pain;Blood lipid;risk factor