【摘要】目的 探讨伴或不伴IR的多囊卵巢综合征(PCOS)患者内分泌指标与超声特征的相关性。 方法 将195例PCOS患者分为IR(PCOS-IR)组和非IR(PCOS-NIR)组，另选健康对照(NC)组50名。检测各组FIns、睾酮(T)、黄体生成素(LH)、卵泡刺激素(FSH)、卵巢体积(OV)、卵泡最大直径等指标。 结果 PCOS-IR组BMI[(22.73±2.38)vs(20.97±2.33)kg/m2，P<0.01]、FIns[(39.22±28.30)vs(6.13±3.59)μU/ml，P<0.01]、胰岛素抵抗指数(HOMA-IR)[(8.40±7.15)vs(1.26±0.75) ，P<0.01]、T[(0.74±0.21)vs(0.53±0.11)ng/ml，P<0.01]和OV[(12.76±3.78)vs (11.43±4.01)ml，P<0.05]大于PCOS-NIR组，卵泡最大直径[(5.08±1.63)vs (7.05±1.72)mm，P<0.01]小于PCOS-NIR组。PCOS患者OV与BMI、HOMA-IR、T、LH/FSH呈正相关，卵泡直径与BMI、HOMA-IR、T呈负相关。 结论 PCOS合并IR患者OV增大，卵泡最大直径减小。OV与IR、高雄激素血症呈正相关，卵泡大小与其呈负相关。IR影响卵巢形态。

　　【关键词】多囊卵巢综合征;胰岛素抵抗;超声影像学

　　【Abstract】Objective To investigate the relation of IR and ovary ultrasonic features in patients of polycystic ovary syndrome (PCOS) with or without IR. Methods 195 PCOS patients were divided into PCOS-IR subgroup and PCOS-NIR subgroup. 50 healthy women served as controls. Serum levels of gonadal hormone, FIns were determined. The ovarian volume (OV), follicle diameter were measured. Results BMI [(22.73±2.38)vs(20.97±2.33)kg/m2，P<0.01], FIns [(39.22±28.30)vs(6.13±3.59)μU/ml，P<0.01], HOMA-IR [(8.40±7.15)vs(1.26±0.75) ，P<0.01], T [(0.74±0.21)vs(0.53±0.11)ng/ml，P<0.01], OV [(12.76±3.78)vs (11.43±4.01)ml，P<0.05] were significantly higher in PCOS-IR group than in PCOS-NIR group, but lower follicle diameter than PCOS-NIR group [(5.08±1.63)vs(7.05±1.72)mm, P<0.01]. The OV were positively correlated with BMI, HOMA-IR, T, LH/FSH. The follicle diameter were negatively correlated with BMI, HOMA-IR, T. Conclusion The PCOS patients with IR shows increased OV and decreased follicle diameter. The OV were positively correlated with IR and hyperandrogenism, negatively correlated with follicle diameter. IR affect ovarian morphology.

　　【Key words】Polycystic ovary syndrome (PCOS); Insulin resistance (IR);Ultrasonography