【摘要】 目的    探讨我国T2DM患者中性粒细胞/淋巴细胞（NLR）与HbA1c的关系。 方法   选取387例T2DM患者，根据HbA1c水平分为HbA1c≤6.0%组68例、6.0%＜HbA1c≤7.0%组165例和HbA1c＞7.0%组154例，比较3组间HbA1c与NLR的差异及二者的相关性。 结果    T2DM患者NLR随HbA1c水平升高而增高[（2.09±0.57） vs （2.17±0.51） vs （2.68±0.48），P＜0.01]。NLR与HbA1c水平呈正相关（r＝0.509，P＜0.01）。Logistic多元回归分析结果显示，影响HbA1c水平的危险因素为NLR及FPG。 结论   NLR、FPG与T2DM患者HbA1c水平呈正相关。
        【关键词】  糖化血红蛋白；中性粒细胞/淋巴细胞；糖尿病，2型

 Investigation of the relationship between neutrophil-lymphocyte ratio and blood glucose level in patients with type 2 diabetes mellitus

        【Abstract】  Objective   To investigate the efficacy and safety of ɑ-glucosidase inhibitor in combination with DPP-4 inhibitor on type 2 diabetes mellitus.  Methods   A total of 120 patients with T2DM were randomly divided into two groups: observation group using ɑ-glucosidase inhibitor in combination with DPP-4 inhibitor (n=60) and control group treated with DPP-4 inhibitor monotherapy (n=60). All patients were followed up for 16 weeks. Blood glucose and biochemical indices were measured at baseline and after treatment. Adverse events and effect of treatment on C-P were observed.  Results   After treatment, FPG[（7.14±1.41） vs （9.02±1.11） mmol/L], 2 hPG[（9.85±1.59） vs （15.28±1.08） mmol/L], HbA1c[（6.68±1.24）% vs （8.24±1.92）%] and C-RP level[（5.14±1.21） vs （8.82±1.71） mg/L] were lower in observation group than in control group. Proportion of patients with targeted HbA1c was higher in observation group than in control group [76.67% (46/60) vs 63.33%(38/60)] (P＜0.05). The differences (Δ value) of blood glucose indicators and C-P level between baseline and after-treatment in both groups were statistically significant (P＜0.05).  Conclusion   ɑ-glucosidase inhibitor in combination with DPP-4 inhibitor has a better effect on T2DM treatment and C-P level than DPP-4 inhibitor monotherapy.
        【Key words】 Hemoglobin A1c （HbA1c）；Neutrophil-lymphocyte ratio （NLR）；Diabetes mellitus，type 2