糖尿病神经病变

　　【摘要】 目的 观察木丹颗粒联合甲钴胺治疗糖尿病周围神经病变(DPN)的疗效。方法 选取DPN患者60例，随机分为治疗(Treatment)组和对照(Con)组,每组各30例。Con组口服甲钴胺;Treatment组口服木丹颗粒联合甲钴胺。疗程均为4周。采用总症状评分(TSS)将两组进行比较。结果 Treatment、Con组用药前后TSS 评分均改善[(5.60±2.81)vs(2.39±1.90)，P<0.01;(5.59±2.17) vs (4.08±2.12)，P<0.01]。两组治疗后TSS评分差异有统计学意义[(4.08±2.12 vs (2.39±1.90)，P<0.01)。结论 与甲钴胺单药治疗相比，木丹颗粒联合甲钴胺可改善DPN患者的临床症状。

　　【关键词】木丹颗粒;糖尿病周围神经病变;甲钴胺;总症状评分

　　【Abstract】 Objective To observe the effects of Mudan granule combined with mecobalamin on the patients with diabetic peripheral neuropathy (DPN). Methods 60 patients with DPN were randomized into control group and treatment group. Thirty patients in control group were given mecobalamin, and thirty patients in treatment group were given mudan granule and mecobalamin，and we followedup all the patients for 4 weeks. Results In both groups, TSS score improved significantly [(5.60±2.81)vs(2.39±1.90), P<0.01; (5.59±2.17)vs(4.08±2.12), P<0.01]after drug therapy. Compared with control group, there was no significant difference [(5.59±2.17)vs (5.60±2.81), P >0.05]in TSS score at baseline; but TSS score decreased significantly[(4.08±2.12)vs (2.39±1.90), P<0.01]in treatment group after 4 weeks follow-up. Conclusion Compared with mecobalamin therapy, the combination of mudan granule and mecobalamin could improve clinical manifestations in patients with DPN.

　　【Key Words】 Mudan granule;Diabetic peripheral neuropathy;Mecobalamin;Total symptom score( TSS)