糖尿病基础研究

　　[摘要] 目的 研究三七对糖尿病大鼠视网膜(DN)治疗效果，并探讨其作用机制。 方法 三七给药8周，观察其STZ诱导糖尿病大鼠视网膜功能及结构的影响。测定血脂、血糖、体重、视网膜胶质纤维酸性蛋白(GFAP)表达水平。结果 三七可改善视网膜的功能和结构。不同剂量三七灌胃,大鼠血糖、TG、视网膜GFAP表达水平均有不同程度的降低(P<0.05或P<0.01)，而体重、HDL-C均有不同程度的增加(P<0.05或P<0.01)。结论 三七是治疗糖尿病及DN的有效措施之一，其机制可能与纠正相关的代谢紊乱及GFAP表达下调有关。

　　[关键词] 糖尿病微血管病变;糖尿病视网膜病变;三七

　　[Abstract] Objective To investigate the therapeutic effect of panax notoginseng for experimental diabetic retinopathy of rats and its mechanism. Methods Diabetes of rats was induced by streptozotocin (STZ). After panax notoginseng administration for 8 weeks, the effects of panax notoginseng on retina function and structure of these rats’ were observed. Blood lipid, blood glucose, weight and retinal glial fibrillary acidic protein (GFAP) expression levels of rats were determined. Results Panax notoginseng can improve retinal structure and function. With giving a gavage of different doses of panax notoginseng, the blood glucose, triglycerides, and retinal GFAP expression levels of the rats were decreased(P<0.05 or P<0.01), and body weight, high-density lipoprotein cholesterol were increased(P<0.05 or P<0.01). Conclusion Panax notoginseng is one of the effective measures to treat diabetes mellitus and diabetic retinopathy. The mechanisms may be related to the amelioration of related metabolic disorders and down-regulated GFAP expression.

　　[Key words] Diabetic microangiopathy; Diabetic retinopathy; Panax notoginseng; Glial fibrillary acidic protein