·文献综述·

　　【摘要】内皮间充质转化(EndMT)即内皮细胞在促成纤维刺激下可获得成纤维细胞样表型。研究显示，EndMT不仅参与人体心脏正常发育，还参与诸多疾病(如肿瘤、糖尿病、高血压等)的发生发展。本文就近年来EndMT发生机制及其相关疾病研究进展作一综述，以期为临床相关疾病治疗提供新靶点。

　　【关键词】内皮间充质转化;肿瘤相关成纤维细胞;糖尿病心肌病;糖尿病肾病

The research progress of endothelial-to-mesenchymal transition YAN Fei,HOU Xin-guo,CHEN Li.Department of Endocrinology, Shandong University, Qilu Hospital, Jinan 250000, China

Corresponding author：CHEN Li，E-mail：chenli3@medmail.com.cn

　　【Summary】 Endothelial cells, under pressure of pro-fibrotic stimuli, will acquire a fibroblast-like phenotype. This type of cellular transition is called endothelial-to-mesenchymal transition (EndMT). According to recent studies, EndMT not only participates the growth of the heart but also contributes to many diseases(as tumor, diabetes, hypertension and so on). This review will focus on the recent advance of pathogenesis of EndMT and may help to provide new targets for the treatment of many diseases.

　　【Key words】 Endothelial-to-mesenchymal transition(EndMT); Cancer associated fibroblasts;Diabetic cardiomyopathy;Diabetic nephropathy(DN)