·糖尿病肾脏疾病·

　　【摘要】 目的 观察二甲双胍及瑞格列奈对糖尿病慢性肾脏疾病(CKD)患者血清转化生长因子-β(TGF-β1)水平的影响。方法 将CKD患者分为二甲双胍(Met)组45例及瑞格列奈(Rep)组45例， Met组予二甲双胍1500 mg/d，Rep组予瑞格列奈6 mg/d，疗程12周。测定两组治疗前后FPG、2 hPG、HbA1c及TGF-β1水平。结果 与治疗前比较，两组FPG、2 hPG、HbA1c及TGF-β1均降低(P<0.05)，与Rep组比较，Met组血清TGF-β1水平下降更明显(P<0.05)。 结论 二甲双胍、较瑞格列奈更能降低CKD患者血清TGF-β1水平，可能延缓CKD进展。

　　【关键词】 糖尿病慢性肾脏疾病;二甲双胍;瑞格列奈;转化生长因子-β1

Effects of metformin and repaglinide on serum TGF-β1 level in patients with diabetic nephropathy  JIN Xiu-ping, WU Peng-fei，WEI Jian-fen. Department of Endocrinology, Affiliated Hospital of Hebei United University, Tangshan 063000, China

　　【Abstract】 Objective To observe the effects of metformin and repaglinide on serum TGF-β1 level in patients with diabetic nephropathy . Methods 90 patients with diabetic nephropathy in Affiliated Hospital of Hebei United University from February 2011 to March 2012 were selected. They were divided into two groups： 45 cases were treated with metformin and the other 45 patients were treated with repaglinide. On the basis of health education, high-quality low protein diet and proper exercise ， metformin group was given metformin 1500 mg/d for 12 weeks，and repaglinide group was given repaglinide 6 mg/d for 12 weeks. The levels of fasting plasma glucose(FPG), 2-hr postprandial plasma glucose (2 hPG), glycosylated hemoglobin (HbA1c),and transforming growth factor-β1(TGF-β1)in two groups were assayed before and after treatments. Results Compared with pre-treatment，FPG, 2 hPG, HbA1c,TGF-β1 in two groups were decreased after treatment(P<0.05). Compared with repaglinide group, TGF-β1 was decreased more significantly in metformin group (P<0.05). Conclusion Metformin may have better effect in reducing serum TGF-β1 level in patients with diabetic nephropathy and delay the progression of diabetic nephropathy than repaglinide.

　　【Keywords】 Diabetic nephropathy; Metformin; Repaglinide; Transforming growth factor-β1