·糖尿病与肥胖、脂代谢异常·

　　【摘要】 目的 探讨炎症因子Fractalkine(FKN)在T2DM患者不同BMI组中的水平变化及与代谢指标的相关性。 方法 纳入139例T2DM患者，根据BMI分为体重正常组(50例)、超重组(44例)及肥胖组(45例)，对相关指标进行统计分析。收集研究对象一般临床资料，测定相关生化指标水平;采用ELISA法检测血清FKN水平。 结果 (1) 3组间血糖、HbA1c比较差异无统计学意义。与正常体重组比较，超重组及肥胖组FKN水平高，而HDL-C水平降低(P均<0.05)。肥胖组BP高于正常体重组，肥胖组血清FKN、ALT、TG水平高于超重组(P均<0.01)。(2)血清FKN水平与BMI(r=0.57,P<0.01)、WC(r=0.40, P<0.01)、TG(r=0.21,P<0.05)呈正相关;多元逐步回归分析结果表明，血清FKN与BMI独立相关(β=0.32, P<0.01,R2=0.40)。 结论 超重和肥胖是T2DM患者FKN水平升高的独立危险因素。

　　【关键词】 Fractalkine(FKN);糖尿病，2型;体重指数(BMI);肥胖症

Relationship of serum fractalkine with metabolic index in patients with type 2 diabetes HUANG Li-ji, XIE Shao-feng，ZHAO Yue,et al. Department of Endocrinology, Affiliated Hospital of Nanjing University of Chinese Medicine，Nanjing 210029，China

Corresponding author: XIE Shao-feng ,E-mail：xiesf3562@sina.com

　　【Abstract】 Objective To investigate the serum fractalkine (FKN) levels in type 2 diabetes patients with different body mass index (BMI) and to analyze the association of serum FKN with metabolic indexes. Methods A total of 139 T2DM patients were enrolled.The basic characteristics and blood chemistries were determined. Serum FKN was measured by enzyme-linked immunosorbent assay (ELISA).According to the levels of BMI，all patients were divided into normal weight group (n=50)，over-weight group (n=44) and obese group (n=45). Results Over-weight and obese group had higher FKN and lower high density lipoprotein cholesterol (HDL-C) as compared with normal weight group. Fasting blood glucose and HbA1c showed no significantly difference among three groups. Blood pressures were higher in obese group than in normal weight group(P<0.05). Serum FKN, alanine aminotransferase and triglyceride were significantly higher in obese group than in overweight group(P<0.05). Spearman analysis showed that serum FKN positively correlated with BMI (r=0.57, P<0.01), waist circumference (r=0.07, P=0.39) and with serum triglyceride (r=0.21, P=0.01). Stepwise linear regression analysis showed that BMI was the independent correlated factor for serum fractalkine concentration. Conclusion Overweight and obesity are the risk factors of fractalkine in type 2 diabetic patients.

　　【Key words】 Fractalkine(FKN);Diabetes mellitus, type 2;Body mass index (BMI);Obesity