文献综述

　　【摘要】二肽基肽酶-4(DPP-4)抑制剂减轻内质网负担和线粒体氧化应激，进而促进胰岛β细胞增殖分化;上调抗氧化应激相关的基因，如Cat、Gpxt及Sod2等，抑制硝基酪氨酸生成;下调脂质合成的基因表达，降低血载脂蛋白B、LDL-C、TG、TC和FFA水平;下调一氧化氮(NO)和TNF-α等炎症因子的浓度;刺激胰岛β细胞分泌胰淀素，但不会促进其的沉积，且对胰淀素所引起的胰岛β细胞的丧失有保护作用;从而改善了胰岛β细胞功能，增加了其质量，延缓了其衰竭。

　　【关键词】二肽基肽酶-4抑制剂;胰岛β细胞;内质网应激;氧化应激;脂毒性

　　【Summary】 DPP-4 inhibitors can alleviate the endoplasmic reticulum stress and mitochondrial oxidative stress to promote the proliferation and differentiation of beta-cells; up-regulate anti-oxidative stress genes, such as Cat, Gpxt and Sod2, and inhibit the production of nitrotyrosine; down-regulate the expression of lipid synthesis genes, and reduce levels of apolipoprotein B, low density lipoprotein, triglycerides, total cholesterol, and free fatty acids; reduce concentrations of inflammatory cytokines like NO and TNF-α; stimulate pancreatic beta-cells to secrete amylin without promoting its deposition, and have protective function for the loss of pancreatic beta cells caused by amylin; therefore improve the function of pancreatic beta cells, increase their mass, and delay their failure.

　　【key words】 DPP-4 inhibitor;Pancreatic beta-cell;Endoplasmic reticulum stress;Oxidative stress;Lipotoxicity