·糖尿病临床研究·

　　【摘要】目的 了解血清25羟维生素D3[25-(OH)D3]与成纤维细胞生长因子23(FGF23)水平在T2DM合并高血压患者中的变化趋势。方法 选取T2DM合并高血压患者40例(DH组)，T2DM无高血压患者40例(T2DM组)以及同期体检的健康人40名(NC组)，检测血清25-(OH)D3和FGF23水平及各项临床生化指标。结果 T2DM组血清25-(OH)D3水平[(31.96±2.13)μg/L]低于NC组[(33.53±2.53)μg/L ](P<0.05)，DH组25-(OH)D3水平[(30.82±2.83)μg/L]较T2DM组更低(P<0.01)。T2DM组FGF23水平[(1.80±0.09)μg/L]高于NC组[(1.14±0.09)μg/L](P<0.01)，DH组FGF23水平[(1.86±0.08)μg/L]较T2DM组更高(P<0.01)。结论 血清25-(OH)D3和FGF23与T2DM合并高血压有关。

　　【关键词】糖尿病;高血压;血清25羟维生素D3;成纤维细胞生长因子23

A study on the changing trend of levels of serum 25-hydroxyvitamin D3 and fibroblast growth factor-23 in the T2DM patients accompanied with hypertension LI Xia, XU Yong, Department of Endocrinology, the Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China

Corresponding author: XU Yong, E-mail: xywyll@yahoo.com.cn

　　【Abstract】Objective To detect the changes of levels of serum 25-hydroxyvitamin D3 [25-(OH)D3] and fibroblast growth factor-23 (FGF23) in the T2DM patients accompanied with hypertension. Methods Forty T2DM patients with hypertension (DH group), 40 T2DM patients without hypertension (T2DM group), and 40 healthy subjects (NC group) were involved in this trial. The measurement of serum 25-(OH)D3 and FGF23 and other clinical biochemical indices was performed for all patients and subjects for observation. Results The level of serum 25-(OH)D3 [(31.96±2.13)μg/L] in the T2DM group was lower than [(33.53±2.53)μg/L] in the NC group (P<0.05), and the level of serum 25-(OH)D3 [(30.82±2.83)μg/L] in the DH group was lower than that in the T2DM group (P<0.01). The level of serum FGF23 of the T2DM group was [(1.80±0.09)μg/L], higher than [(1.14±0.09)μg/L] of the NC group (P<0.01), and the level of serum FGF23 of the DH group was [(1.86±0.08)μg/L], higher than that of the T2DM group (P<0.01). Conclusion The levels of serum 25-(OH)D3 and FGF23 are related to the T2DM accompanied with hypertension.

　　【Key words】Diabetes mellitus; Hypertension; Serum 25-hydroxyvitamin D3 [25-(OH)D3]; Fibroblast Growth Factor-23 (FGF23)