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氨氯地平联合厄贝沙坦对糖尿病合并高血压患者血压晨峰现象影响的观察

来自:中国糖尿病杂志  编辑:朱一帆 魏曦 陈茜 |点击数:|2013-04-24

  ·糖尿病临床研究·

  氨氯地平联合厄贝沙坦对糖尿病合并高血压患者血压晨峰现象影响的观察

  朱一帆 魏曦 陈茜 李春陵 袁志柳 王静

  【摘要】 目的 探讨氨氯地平联合厄贝沙坦对糖尿病合并高血压患者血压晨峰(MBPS)现象的影响。方法 将80例患者随机分为实验(氨氯地平联合厄贝沙坦)组和对照(氨氯地平)组,观察服药前及服药后4、8周清晨血压的变化,比较4、8周后两组患者MBPS下降程度。结果 4、8周后两组MBPS较治疗前均下降(P<0.05),实验组下降幅度大于对照组(P<0.01)。8周后,实验组MBPS控制有效率为92.5%,对照组为60%,实验组高于对照组(P<0.05)。结论 氨氯地平联合厄贝沙坦较单独使用氨氯地平更能有效控制糖尿病合并高血压患者MBPS现象。

  【关键词】氨氯地平;厄贝沙坦;糖尿病;高血压;血压晨峰

Effect of amlodipine and irbesarta in combination on morning blood pressure surge in diabetic patients associated with hypertension ZHU Yi-fan, WEI Xi, CHEN Qian, et al. Guizhou Provincial People's Hospital, Guiyang 550002, China

  【Abstract】Objective To study the effect of Amlodipine and Irbesarta in combination on morning blood pressure surge (MBPS) in diabetic patients associated with hypertension. Methods Eighty diabetic patients associated with hypertension were randomized into experimental group (amlodipine + irbesarta) and control group (amlodipine). The observation on the changes in morning blood pressure surge (MBPS) 4 and 8 weeks after medication respectively was carried to compare the decrease of MBPS between the two groups. Results Four and eight weeks after medication, there was a decrease of MBPS in both groups (P<0.05), while the decrease in the experimental group was more significant than in the control group (P<0.01). Eight weeks after medication, the effective controlling rate of blood pressure in the experimental group was 92.5%,higher than 60% in the control group (P<0.05). Conclusion Amlodipine in combination with irbesartan is more effective than using amlodipine only in controlling MBPS of the diabetic patients associated with hypertension.

  【Key words】 Amlodipine; Irbesartan; Diabetes; Hypertension; Morning blood pressure surge (MBPS)

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